Ambrisentan - Drug Information
Generic Name : Ambrisentan
Pronunciation : am-bree-SEN-tan
ICD Code : Y52.5 | Therapeutic Classification : Anti- Hypertensives
Trade Name(s) :
India - Endobloc (5mg), Endobloc (10mg)International - Letairis.
Why is Ambrisentan Prescribed? (Indications)
This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel.
When should Ambrisentan not to be taken? (Contraindications)
♦ Contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF), pregnant women and known hypersensitivity. It should not be co-administered with cyclosporine.What is the dosage of Ambrisentan?
PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily.
How should Ambrisentan be taken?
It comes as a tablet to take by mouth, with or without food.
What are the warnings and precautions for Ambrisentan?
* Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding.* Monitor liver function, complete blood count regularly while taking this medication.
What are the side effects of Ambrisentan?
Most common - Peripheral edema, nasal congestion, inflammation of sinuses, flushing, palpitations inflammation of nasopharynx, abdominal pain, nausea, loss of appetite, low fever, itching, constipation and difficulty in breathing.Central Nervous System- Headache.
Blood- Decrease in hemoglobin level.