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Reducing Tumor-associated Immune Cell Protein Decreases Tumor Progression

by Bidita Debnath on  July 9, 2013 at 6:10 PM Cancer News   - G J E 4
In cancer patients, the number of tumor-associated immune cells is correlated with poor prognosis.
 Reducing Tumor-associated Immune Cell Protein Decreases Tumor Progression
Reducing Tumor-associated Immune Cell Protein Decreases Tumor Progression
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Reducing these cells in mouse models of breast cancer reduces tumor metastasis, indicating that tumor-immune interactions are critical for cancer progression. In this issue of the Journal of Clinical Investigation, Shelley Earp and colleagues at the University of North Carolina a Chapel Hill demonstrate that removal of the protein MerTK from immune cells decreased tumor growth in mouse models of breast cancer, melanoma, and colon cancer.

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Loss of MerTK reduced the release of molecules associated with inflammation. These findings suggest that drugs that inhibit MerTK may stimulate anti-tumor responses and could potentially have clinical benefit.

Source: Eurekalert
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