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Promising Results Seen With Drug With Unique Disruption of Tumor Blood Flow
Results of this study, which were presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, support ongoing Phase III studies of ASA404 in NSCLC.
Under development by Novartis, who licensed the drug from Antisoma, ASA404 (vadimezan) has a unique mechanism of action against a tumor's blood supply. Scientists have long known that choking off this blood supply through a process called anti-angiogenesis is one way to slow tumor growth. Bevacizumab (sold as Avastin by Genentech) is one of many angiogenesis inhibitors and has had a major impact on patient care.
"Bevacizumab, however, predominantly interferes with the formation of new blood vessels," said lead researcher Mark McKeage, Ph.D., an associate professor in clinical pharmacology at the University of Auckland. "ASA404 has been shown to cause selective disruption of the established tumor vasculature, inhibition of tumor blood flow and tumor necrosis."
This unique mechanism of action could provide an option for patients with either squamous or non-squamous NSCLC. Treatment options for patients with advanced stage NSCLC are limited, particularly for those with squamous histology where some treatments exhibit limited efficacy or serious side effects.
"Standard chemotherapy is currently the mainstay of treatment for patients with squamous NSCLC. New targeted therapies and chemotherapies have been evaluated, but many show little promise as first-line treatments in patients with this type of cancer," said McKeage.
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