New Stroke Treatment

by Sheela Philomena on  July 13, 2011 at 12:59 PM Research News
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A nontoxic treatment for stroke has been identified by a team of researchers led by Gregory Bix, at Texas A&M College of Medicine, College Station. Researchers have identified a method to exploit one of the brain's self-repair mechanisms to protect nerve cells and enhance brain repair in rodent models of stroke.
 New Stroke Treatment
New Stroke Treatment

The most common form of stroke (ischemic stroke) occurs when a blood vessel that brings oxygen and nutrients to the brain becomes clogged, for example with a blood clot, causing nerve cells in the affected area to die rapidly. In their study, Bix and colleagues detected in rodent models of stroke elevated levels of domain V, a naturally occurring fragment of the molecule perlecan, suggesting it might have a natural role in repairing the brain after a stroke. When administered in these models 24 hours after stroke, perlecan domain V protected nerve cells from death and promoted blood vessel growth, a key component of brain repair. The authors therefore suggest that perlecan domain V could provide a therapy that improves stroke outcome by protecting nerve cells and enhancing brain repair.

Source: Eurekalert

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