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New Light Shed On Breast Cancer Gene BRCA1
January 16, 2008 at 7:44 PM
Cancer News
The study, led by Craig Bennett, Ph.D., a researcher in Dukes Department of Surgery, stated that the finding could lead to more effective therapies for women with and without mutated copies of the BRCA1 (Breast Cancer 1, early onset) gene.
Since it was discovered in 1994, BRCA1 and its role in preventing and causing cancer has been intensely studied, and our research represents an important piece of the puzzle, Bennett said.
This study has identified an important mechanism by which BRCA1 comes into play when DNA -- the basis for all cell function -- is damaged. We have shown that this theory holds up not just in scientific models but in human breast cancer cells as well, he added.
In the study, the researchers looked at yeast to demonstrate that a molecular pathway that is particularly susceptible to BRCA1 influence is also crucial to normal cell function.
The BRCA1 pathway we discovered is directly involved with the critical process of transcription, in which RNA acts as a messenger between DNA and the making of proteins," Bennett said.
Bennett said that DNA damage is a normal result of exposure to environmental agents, such as carcinogens, and the response to this damage can be influenced by other normal human processes such as aging and hormonal changes.
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More News on: Women and Cancer, DNA Finger Printing, Breast Biopsy, Pagets disease of the breast, Mastitis, Cancer and Homeopathy, Breast Cancer Facts, Cancer Facts, Cancer, Breasts - Structures and Types
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