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Indian American Shuts Down Protein That Causes Ovarian cancer
'The protein interleukin-8 (IL-8) is a potential therapeutic target in ovarian cancer,' said Dr. Anil Sood, a professor in the M. D. Anderson Departments of Gynecologic Oncology and Cancer Biology.
Writing about the research team’s findings in a paper, published in the Journal of the National Cancer Institute, Dr. Sood said that high IL-8 expression in tumours is associated with advanced tumour stage, and earlier death for ovarian cancer patients.
He revealed that experiments conducted on a mouse model had revealed that short interfering RNA (siRNA) could cut IL-8 expression, and reduce tumour size by attacking its blood supply.
'This comprehensive analysis - with human data, animal data and lab experiments to highlight the molecular mechanisms involved - helps us develop the new targets needed for a more effective approach against ovarian cancer,' Dr. Sood said.
Pointing out that IL-8 is over-expressed in many types of cancer, Dr. Sood added: 'In the long run, this research will have applications in other cancers as well.'
During the study, the researchers tested a specific siRNA against two lines of ovarian cancer in a mouse model. They packaged siRNA that stymies IL-8 into a small ball of fat known as a liposome, a combination they developed because siRNA is hard to deliver to tumours.
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