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Cancer Gene Expression Trends Indentified in Developmental Stages: Study

by Thilaka Ravi on  August 18, 2008 at 3:05 PM Cancer News   - G J E 4
 Cancer Gene Expression Trends Indentified in Developmental Stages: Study
Scientists from Children's Hospital Boston and Harvard University claim to have uncovered the trends in cancer gene expression in the early developmental stages of different human tissues.
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The team led by Isaac S Kohane performed a comprehensive comparison of genes expressed in early developmental stages of various human tissues and those expressed in different cancers affecting these tissues.

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"Our study reveals potentially clinically relevant differences in the gene expression of different cancer types and represents a reference framework for interpretation of smaller-scale functional studies," he said.

One of the three described groups of cancers has an early developmental phenotype and expresses genes that are characteristic of stem cells.

A second, more heterogeneous group tends to be more similar to late development and is characterized by an inflammatory signature.

The third is a small group of cancers that present as a transition phenotype between these two extremes and displays both characteristics.

"This segregation of tumors into three groups with distinct expression patterns is surprising. Clearly, the developmental trajectory provides a meaningful background for capturing large-scale differences in gene expression across diverse conditions," said Kohane.

The research is published in BioMed Central's open access journal Genome Biology.

Source: ANI
THK/L
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