About My Health Careers Internship MedBlogs Contact us

US Cancels Plan to Test Experimental AIDS Vaccine

by VR Sreeraman on July 19, 2008 at 12:15 PM
Font : A-A+

 US Cancels Plan to Test Experimental AIDS Vaccine

US scientists have scrapped plans for a large trial of a HIV vaccine due to concerns about its effectiveness, the government's medical research agency said.

The decision on the government-developed vaccine comes less than a year after a trial for a similar vaccine from the pharmaceutical company Merck failed -- marking another setback in the decades-long struggle to develop a successful vaccine to fight the scourge of AIDS.


The National Institute of Allergy and Infectious Diseases (NIAID), part of the government's National Institutes of Health, said after consulting scientists and advocacy groups it "has determined that it will not conduct the HIV vaccine study known as PAVE 100."

"However, NIAID believes the vaccine developed by its Vaccine Research Center (VRC) is scientifically intriguing and sufficiently different from previously tested HIV vaccines to consider testing it in a smaller, more focused clinical study," the agency said in a statement issued on Thursday.

The smaller-scale study would examine if the vaccine regimen lowers the amount of HIV in the blood of vaccinated individuals, the agency said.

The trial, which was to involve 8,500 volunteers in the United States, South America, the Caribbean and Africa, had been viewed as a test of a promising vaccine that uses virus strains from around the world to prompt immunity.

The failure of Merck's vaccine influenced the decision to cancel the planned trial of the government's PAVE vaccine, US media reported on Friday.

The Merck vaccine in tests failed to prevent HIV infection or reduce the amount of HIV in the blood of patients, the government agency said.

Results also indicated that it may have even increased the risk of infection for some patients.

The official who canceled the PAVE trial, Doctor Anthony Fauci, director of the NIAID, said a large trial was not justified until fundamental questions could be answered about how the vaccine operates.

"Show me that the vaccine works by lowering the amount of HIV in the blood," Fauci was quoted as saying by the New York Times.

"Then we will move to a larger trial that will document the link with a particular immune response," he said. Until then, "doing a large trial is not justified."

The agency said it would continue to strive to find an AIDS vaccine, an effort that began more than 20 years ago.

"An HIV vaccine continues to be our best hope for ending the HIV pandemic," it said.

"NIAID is committed to supporting the basic research and vaccine discovery needed to design promising vaccine candidates and testing those candidates when appropriate."

Source: AFP

News A-Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs AIDS - Initial Theories and Disease Progression AIDS/HIV - Worldwide distribution and Risk of Transmission 
Recommended Reading
AIDS - Initial Theories and Disease Progression
AIDS was first detected in early 1980s, among gays, Haitians and black Africans. HIV is a descendant...
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
AIDS/HIV - Worldwide distribution and Risk of Transmission
Epidemiologic studies indicate three broad yet distinct geographic patterns of transmission...
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use