About My Health Careers Internship MedBlogs Contact us

Stunning New Discovery About Cholera Bacterium

by Kalyani Thivakaran on January 4, 2015 at 3:43 PM
Font : A-A+

 Stunning New Discovery About Cholera Bacterium

Scientists have recently discovered a new truth about the Cholera causing bacterium Vibrio cholerae (V cholerae) that infects the small intestine, which is characterized by acute watery diarrhea resulting in severe dehydration. Scientists have found that the cholera bacterium follows an unconventional way in which it the stabs and kills other bacteria to steal their DNA, making it potentially more virulent.

The research group from the Ecole Polytechnique Federale de Lausanne, Switzerland, has now demonstrated that the cholera bacterium uses a tiny spear to stab and kill neighboring bacteria, even of its own kind, and then steal their DNA. They call this mechanism as "horizontal gene transfer," and the bacterium becomes potentially more virulent by absorbing the traits of its prey.


Ms. Melanie Blokesch at EPFL found that V cholerae uses a predatory killing device, a spring loaded spear, which constantly shoots out in all ways, to compete with surrounding bacteria and steal their DNA. This weapon is called the "type VI secretion system" (T6SS) and is known to exist in many types of bacteria.

V cholerae attacks any bacterium that is in its proximity with the spear and the spear punches a hole into them. This leads to the death of the other bacteria and release of their genetic material, which the predator pulls into itself. This spear-killing, predatory behavior is triggered by the bacterium's environment. The cholera bacterium naturally lives in water, such as the sea, where it attaches onto small planktonic crustaceans. There, it feeds on the main component of their shells, which is a sugar polymer called chitin.

V cholerae goes into an aggressive survival mode called "natural competence," when chitin is available. Ms. Blokesch's lab tested different strains of the bacterium from all over the world. The researchers grew these bacteria on chitin surfaces that simulated their natural habitat on crustaceans.

They found that the tiny spear is not only part of V cholerae's natural survival system, but it also contributed to the transfer of genes that could make the bacterium more resistant to threats, even to antibiotics. On this, Ms. Blokesch commented that, "Using this mode of DNA acquisition, a single V cholerae cell can absorb fragments containing more than 40 genes from another bacterium."

The researchers said that the importance of this study lies in the fact that horizontal gene transfer is a widespread phenomenon in bacteria, and it contributes to the dispersal of virulence factors and antibiotic resistances. In addition, this molecular spear might also kill protective bacteria in the human gut when the chitin-mediated activation of the spear-killing device in the bacterium is ingested by patients, hence making it more dangerous. The study is published in the journal Science.

Source: Medindia

News A-Z
News Category
What's New on Medindia
Good Nutrition Linked to Better Mental Health in School Children
Convulsions / Seizures / Fits - Symptom Evaluation
World Heart Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholera Water Borne Diseases Amoebic Dysentery 

Recommended Reading
Cholera is an infection of the small intestine and is caused by the bacterium Vibrio cholerae....
Antibiotics may be Beneficial in Moderate Cholera
In contrast to the WHO recommendations, some researchers advocate the use of antibiotics in ......
Containing Cholera: An Interview
Cholera, as we know, is an infectious disease caused by the bacterium Vibrio cholerae. The mode of ....
Health Effects of Global Warming
Greenhouse effect causes excessive heat to build up in the earth's atmosphere causing global ......
Amoebic Dysentery
Amoebic dysentery or amoebiasis is an infection of the intestine that causes diarrhoea most frequent...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use