A genetic variant associated with multiple psychiatric disorders may increase an individual's risk of developing bipolar disorder and schizophrenia, finds a study published in JNeurosci.
Stéphane Jamain and colleagues used genetic analysis and neuroimaging in samples of adults with schizophrenia, early-onset bipolar disorder and healthy controls in addition to postmortem analysis of brain tissue from schizophrenia patients to demonstrate that a variant of a gene involved in neurotransmission is associated with both disorders.
They found that this genetic variation changes the expression of the SNAP25 protein in the brain, which may impact information processing between brain regions involved in regulating emotions. Consistent with this idea, the variant was associated with larger amygdala volume and altered prefrontal-limbic connectivity.
The research confirms a shared genetic component of these disorders and points to a potentially new condition that may arise in patients with varying diagnoses in which this gene is implicated, such as attention-deficit/hyperactivity disorder.