A new approach that may offer treatment options for pancreatic cancer has been suggested by researchers from Shanghai Jiao Tong University, China.
It is already known that overexpression of epidermal growth factor receptor or EGFR can result in cancer and targeting EGFR pathway as a potential therapeutic strategy for pancreatic cancer has been developed.
Chemotherapy
''Chemo'' means medicine or ''drug'', ''therapy'' means ''treatment''. Chemotherapy refers to the use of cytotoxic drugs in the treatment of cancer.
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Erlotinib is a small molecule tyrosine kinase inhibitor that efficiently blocks EGFR.
The study showed significant improvement in survival with the addition of erlotinib.
The research team from Department of Gastroenterology, Affiliated First People's Hospital, Shanghai Jiao Tong University, China studied the effects of erlotinib on six different pancreatic cancer cell lines.
![Chemotherapy Drugs]( "Chemotherapy Drugs")
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body.
The researchers revealed the efficacy of erlotinib, as a single agent, on pancreatic cancer cells growth in vitro, and in vivo study using a nude mice xenograft model and the mechanisms involved were also explored.
They found that Erlotinib repressed BxPC-3 cell growth in a dose-dependent manner, triggered G1 arrest and induced cell death, and suppressed capillary formation of endothelium in vitro.
In vivo, erlotinib treated mice demonstrated a reduced tumour volume and weight as compared with control.
These findings provide evidence for the inhibitive activity of erlotinib in pancreatic cancer cells. Inhibition of EGFR may be a promising adjuvant in chemotherapeutic strategy in the treatment of the dreary disease.
The study was published in the World Journal of Gastroenterology.
Source: ANI
RAS/SK
The research team from Department of Gastroenterology, Affiliated First People's Hospital, Shanghai Jiao Tong University, China studied the effects of erlotinib on six different pancreatic cancer cell lines.
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body.
Advertisement
The researchers revealed the efficacy of erlotinib, as a single agent, on pancreatic cancer cells growth in vitro, and in vivo study using a nude mice xenograft model and the mechanisms involved were also explored.
They found that Erlotinib repressed BxPC-3 cell growth in a dose-dependent manner, triggered G1 arrest and induced cell death, and suppressed capillary formation of endothelium in vitro.
In vivo, erlotinib treated mice demonstrated a reduced tumour volume and weight as compared with control.
These findings provide evidence for the inhibitive activity of erlotinib in pancreatic cancer cells. Inhibition of EGFR may be a promising adjuvant in chemotherapeutic strategy in the treatment of the dreary disease.
The study was published in the World Journal of Gastroenterology.
Source: ANI
RAS/SK
Liver Cancer Treatment - Animation
Liver Cancer is the uncontrolled growth of cells in the liver. The present section provides a graphic description of the various forms of liver cancer treatment in addition to the latest techniques such as Chemoembolisation and Radio frequency Ablation.
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