A new scientific study may give you the best solution to the hangover from last night's binge drinking - a cup of steaming hot coffee and a painkiller.
Researchers at Thomas Jefferson University in Philadelphia, Pennsylvania, conducted the study in mice, in which they injected doses of ethanol.
The doses usually trigger headaches in people prone to migraine. Michael Oshinsky and his colleagues found that 4 to 6 hours later, the skin around the rats' eyes became sensitive to touch, indicating that they were suffering from a headache, reports New Scientist.
The reason caffeine and over-the-counter anti-inflammatory drugs seem to provide relief is because they block some of the effects of acetate.
If that really is the case, the best time to take them would be about 4 hours after drinking, when acetate levels begin to increase.
Dan Levy at Harvard University is wary of calling the rats' headache a hangover, but says the study is an important step towards understanding alcohol-triggered headache.
The study appears in PloS.