People having obesity, high blood pressure and high blood sugar simultaneously are twice likely to have a heart attack and three times more likely to die earlier than the general population.
Experts at the University of Warwick identified the three killer indicators as the most dangerous combination of health factors when developing metabolic syndrome, a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes.
Lead researcher Dr Oscar Franco, Assistant Clinical Professor of Public Health at Warwick Medical School, and colleagues sought to determine the prevalence and progress of Metabolic Syndrome as part of the Framingham Offspring Study.
He said: "Metabolic syndrome is a highly prevalent condition that is increasing dramatically and affects a large portion of the middle-age population. Not all individuals enter the syndrome with identical combination of factors. Certain combinations confer higher risks of incident cardiovascular disease and mortality."
He added: "Intense efforts are needed to identify populations with these particular combinations and to provide them with adequate treatment at the early stages of disease."
The 'Trajectories of Entering the Metabolic Syndrome: the Framington Heart Study' has been published in the American Heart Association journal Circulation.