Creator: Dr. Reeja Tharu
Keywords: genetic counseling, genes, Huntington's disease, genetic disorders, infertility,miscarriage, Down's syndrome, DNA, alpha-fetoprotein, pedigree, cytogenic diagnosis, molecular diagnosis, polymerase chain reaction, mendelian inheritance, autosomal recessive,autosomal dominant,X-linked recessive, X-linked dominant,non-mendelian inheritance,polygenic defects, multifactorial inhertance

Estimation of Risks of Genetic Counselling

X- LINKED DOMINANT

Example

Familiar hypophosphataemia.

FEATURES

Females - More likely to be affected
No father to son transmission
Lethal in males if Affected
50% Affected offspring.

Another the non - Medilan inheritance is called " Mitochondrial Inheritance "

Non Mendelian Inheritance

Affects only males : Father to son transmission.
Often mutated / altered genes - Fertility genes that assist in normal spermatogenesis – Lead to Male infertility

Example

Y - Micro deletions of the A2 F loci. ( A2Fa, A2Fb, A2Fc ) ; but highest incidence with A2FC locus ). - 100% Risk.