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Estimation of Risks of Genetic Counselling


Estimation of Risks of Genetic Counselling

X- LINKED DOMINANT 

Leprosy

Example 

Familiar hypophosphataemia.

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  • Females - More likely to be affected 
  • No father to son transmission 
  • Lethal in males if Affected 
  • 50% Affected offspring. 

Another the non - Medilan inheritance is called " Mitochondrial Inheritance " 

Non Mendelian Inheritance 

  • Affects only males : Father to son transmission. 
  • Often mutated / altered genes - Fertility genes that assist in normal spermatogenesis – Lead to Male infertility 

Example 

Y - Micro deletions of the A2 F loci. ( A2Fa, A2Fb, A2Fc ) ; but highest incidence with A2FC locus ). - 100% Risk.

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