Dr. Namitha Kumar's Profile
MA - English, PhD (Psychology)
Her deepest passion is working on human experience of disability. She holds a PhD in Psychology. She is also interested in experiences of chronic and genetic illnesses.
Written / Edited / Medically Reviewed
For the first time, scientists have used CRISPR-Cas9 guided gene editing to prevent genetic disorders before birth. An effective tool was used for prenatal gene editing to edit out disease-causing genes in the fetus.
An important signaling protein that regulates the production of hemoglobin was discovered. Blocking this protein can increase fetal hemoglobin production and deliver therapeutic benefits to Sickle Cell Disease (SCD) and Beta-Thalassemia.
Unexpected DNA changes and off-target mutations in CRISPR-Cas9 edited mouse and human cells were reported in recent research. CRISPR-Cas9 has been heralded as the gene editing tool of choice to correct genetic disorders.
Familial risk of heart failure: There is limited understanding of genetic mechanisms leading to heart failure. Though the cardiomyopathies are fairly well documented, we need more studies on the heritability of heart failure. Understanding this will go a long way in improving public health.
Monogenic hereditary disorders are largely responsible for child mortality and morbidity. However, intrauterine genetic editing could correct the genetic defect and thereby cure the disease in the fetus.