Osmotic Fragility of Erythrocytes in various diseases

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Disease	Initial Hemolysis	Complete Hemolysis
Normal	0.44	0.32
Hereditary spherocytosis	0.68	0.46
Acquired hemolytic anemia	0.52	0.42
Hemolytic disease caused by ABO incompatibility	0.50	0.40
Hemolytic disease caused by Rh incompatibility	0.60	0.40
Hemolytic anemia caused by drugs	0.50	0.40
Hemolytic anemia caused by burns	0.50	0.40
Pernicious anemia	0.48	0.36
Congenital nonspherocytic hemolytic anemia	0.44	0.32
Elliptocytosis, asymptomatic	0.44	0.32
Elliptocytosis with hemolytic anemia	0.50	0.32
Thalassaemia	0.38	0.20
Sickle cell anemia	0.36	0.20
Sickle Cell trait	0.44	0.32
Hb C disease	0.34	0.22
Erythremia	0.40	0.28
Iron deficiency anemia	0.38	0.28
Obstructive jaundice	0.36	0.28

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