Indications : This test is used to diagnose "hairy cell leukemia"/ "Leukemic reticuloendotheliosis"
Physiology : There are six isoenzymes of leukocyte acid phosphatase. Isoenzyme V is not inhibited by L (+) tartaric acid. Malignant nuclear cells of leukemic reticuloendotheliosis contain isoenzyme V and are resistant to inhibition by L (+) tartaric acid.
Normal Range : Most white cells of peripheral blood as well as platelets are acid phosphatase positive.
Test Method : Naphthol AS-BI, fast garnet GBC, with and without L(+) tartaric acid.
Related Tests : Leukocyte Cytochemistry, Lymph node biopsy
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