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Diagnosis of Pleural Effusion

Medically Reviewed by Dr. Sunil Shroff, MBBS, MS, FRCS (UK), D. Urol (Lond) on Sep 30, 2016


Diagnosis of Pleural Effusion

Thoracentesis may be performed for diagnosis or therapy. The classical pattern of examination includes inspection of the respiratory system, palpation, percussion (tapping) and auscultation.


Diagnosis of pleural effusion begins with elicitation of a proper medical history of the patient. Examination includes inspection of the respiratory system, palpation, percussion (tapping) and auscultation. Air entry is usually restricted by fluid collection, percussion classically yields a 'stony dull' note. A friction rub or squeak may be heard if there is inflammation of the pleura (pleurisy).

Thoracentesis may be performed for diagnosis or therapy. A long thin needle is injected into the pleural space to remove fluid that is sent for testing to confirm the diagnosis. This is also used for treatment. As a rule, newly discovered effusions should be tapped. A number of conditions act as relative contraindications for tapping. These include bleeding diathesis, anticoagulation, a small volume of fluid, mechanical ventilation, and a low benefit-to-risk ratio.

While diagnostic tapping takes 30 to 50 ml of pleural fluid for analysis, therapeutic tapping takes a larger amount (no more than 1000 to 1500 mL at one time).

Light's criteria for exudates-any of following:

Pleural fluid/serum protein ratio > 0.5

Pleural fluid/serum LDH ratio > 0.6

Pleural fluid LDH >23 the normal upper limit for serum

Alternate diagnoses (Differential diagnoses) include hemothorax (blood collection in the cavity), pneumothorax (presence of air) and empyema (collection of pus).

Pleural Effusion - References

  1. Cecil Medicine, 23rd Ed.
  2. Harrison''s PRINCIPLES OF INTERNAL MEDICINE, 17TH� Edition
  3. Macleod�s Clinical Examination, 12th Ed.

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