CRISPR-Cas9 System to Treat Age Related Macular Degeneration

Highlights:

• A research team from The Institute of Basic Science utilized pre-assembled CRISPR complex called Cas9 ribonucleoprotein
• This pre-assembled complex modified the VEGF gene locally and degenerated within 72 hours
• Potential treatment for age related macular degeneration identified

Scientists have developed a gene surgery in the tissue layer supporting the retina which promises to be a potential form of therapy for patients with age related macular degeneration. Among people over the age of 65 years, one in 10 people show signs of this condition, with its prevalence increasing with age. Age related macular degeneration (AMD) occurs commonly among Caucasians, resulting in blind spots and vision distortion. The study published in the journal Genome Research is based on laboratory studies as well as animal studies.

(http://care.diabetesjournals.org/content/26/suppl_1/s99)

‘CRISPR-Cas9 system can now be used to cure age related degenerative diseases and retinopathy through gene therapy.’

Source: Medindia

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