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Sedative Drug Counteracts Cocaine-induced Symptoms
“We have found that cocaine’s effects on the cardiovascular system can be reversed by the use of a drug called dexmedetomidine, which is currently approved by the Food and Drug Administration for anaesthetic purposes in operating rooms or intensive care units,” said Dr. Wanpen Vongpatanasin, associate professor of internal medicine and senior author of a study published in the Journal of the American College of Cardiology.
The researchers have found that dexmedetomidine effectively reverses the action of cocaine on heart rate, blood pressure, and vascular resistance in the skin by interfering with the ability of cocaine to increase nerve activity.
“Typically, patients with cocaine overdoses in the emergency room are treated with nitroglycerin, sedatives such as Valium, and some blood-pressure medications such as calcium channel blockers and some beta blockers,” Dr. Vongpatanasin said.
“However, the standard treatments don’t alleviate all of the adverse effects of cocaine on the heart, blood pressure and central nervous system” she added.
The researchers administered a small, medically approved dose of cocaine nose drops to 22 healthy adults who had never used cocaine. It doubled sympathetic nerve activity, part of the body’s “automatic” response system that becomes more active during times of stress, in the participants.
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