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Osteoporosis Due to Age, Not Estrogen Fall

by Tanya Thomas on  March 2, 2010 at 8:40 AM Women Health News   - G J E 4
 Osteoporosis Due to Age, Not Estrogen Fall
Scientists at the University of Arkansas for Medical Sciences (UAMS) have identified an age-related mechanism - not a decrease of the hormone estrogen - as the primary culprit behind osteoporosis.
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The research team, led by Stavros Manolagas, in the UAMS Center for Osteoporosis and Metabolic Bone Diseases, said that aging and the body's increased inability to defend against bone-damaging molecules produced through a process known as oxidative stress are most directly responsible for the bone-weakening disease - and perhaps other age-related diseases.

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Researchers found that age weakens the defenses against oxidative stress.

In particular, an age-related loss of certain proteins that defend against oxidative stress increase the risk of osteoporosis.

Manolagas said conditions such as a loss of estrogen can further decrease the molecular defenses against oxidative stress.

"We feel like we have turned a page in our understanding of osteoporosis," said Manolagas.

"This emerging evidence provides a paradigm shift from the 'estrogen-centric' view of what causes osteoporosis to one in which these age-related mechanisms are the main protagonists and other changes - including the reduction of estrogen - accentuate them," Manolagas added.

The research was detailed in an article in the Feb. 3 issue of the journal Cell Metabolism.

Source: ANI
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