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Control Mechanism for Metastasis of Breast Cancer Cells Identified
Metastasis is the main cause of cancer death. It is described as the transfer of cancer cells from the original tumour to distant organs via the blood stream.
The new findings add significantly to the understanding of metastasis, and may lead to the development of anti-cancer drugs in the future.
Led by Prof. Yosef Yarden of the Institute's Biological Regulation Department, the researchers mapped all of the genetic changes that occur in the cell when it receives a signal from a growth factor, a substance that orders cells to "prepare to move".
As they sifted through the enormous amount of data they received, including details on every protein level that went up or down, one family of proteins stood out. Tensins, as they are called, are proteins that stabilize the cell structure. But to the scientists' surprise, the amounts of one family member rose dramatically while, at the same time, the levels of another dropped.
When the scientists conducted experiments with genetically engineered cells, they found that the growth factor directly influences levels of both proteins, and that these, in turn, control the cells' ability to migrate.
While blocking the production of the short tensin protein kept cells in their place, its overproduction increased their migration.
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More News on: Women and Cancer, Breast Biopsy, Pagets disease of the breast, Mastitis, Cancer and Homeopathy, Parkinsons Disease Surgical Treatment, Breast Cancer Facts, Cancer Facts, Cancer, Breasts - Structures and Types
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