Amiodarone/ Cordarone - Drug Toxicity
Indication : Amiodarone is an anti-arrhythmic drug.
Physiology : Amiodarone is a class III antiarrhythmic agent approved for the treatment of life threatening ventricular tachyerrhythmias. Because of the potential toxicity the serum level of this drug should be monitored.
Normal Values : 0.5-2.5 mg/L (>7 mmol/L).
Critical Values : Adverse effects at > 2.5 mg/L (>4 mmol/L).
Test Method : High Performance Liquid Chromatography (HPLC).
Side effects : Amiodarone affects the metabolism of other cardioactive drugs; serum concentrations and pharmacological effects of the drugs can be increased. The use of the drug is restricted because of its many side effects, including pulmonary fibrosis, neuromuscular weakness, and exacerbation of congestive heart failure, tremor, thyroid dysfunction, and interaction with other drugs.
Related Drugs : Liver profile, Thyroid Stimulating Hormone, Thyroxine