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Aflibercept

Latest prescription information about Aflibercept. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Aflibercept
Therapeutic Classification : Glycoprotein
Trade Name(s): 
Internaional- Eylea.
Why it is prescribed (Indications) : 
This medication is a dimeric glycoprotein, prescribed for neovascular (Wet) age-related macular degeneration (AMD). It decreases the growth of certain cells in the eye.
When it is not to be taken (Contraindications): 
Contraindicated in patients with ocular or periocular infections, intraocular inflammation, and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Intravitreal- The recommended dose is 2 mg (0.05 mL or 50 microliters) administered by injection every 4 weeks (monthly) for 3 months, followed by 2 mg (0.05 mL) once every 8 weeks (2 months).
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider into the eye.
Warnings and Precautions : 
* Caution should be exercised in patients with history of increased eye pressure, during pregnancy and breastfeeding.
* Patient may develop with increased risk of endophthalmitis and retinal detachments, blood clot events; if it is so consult with your doctor.
Side Effects : 
Most Common - Conjunctival bleeding, eye pain, cataract, vitreous detachment, increased eye pressure, foreign body sensation, increased tears, blurred vision, eye swelling.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2°C to 8°C).


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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