Doctors'' Guide to Unexplained Illness Points to B1 Deficiency

Monday, October 1, 2018 General News
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Derrick Lonsdale and Chandler Marrs tell how thiamine deficiency gives rise to the classic disease of beriberi, which can be considered the prototype for a set of disorders in new book.

NEW YORK, Oct. 1, 2018 /PRNewswire-PRWeb/ -- "This book is a great overview to various clinical problems seen in thiamine

deficiency. I highly recommend it." – Nathan Eliason, Amazon reviewer

"Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition" explores how thiamine deficiency affects the functions of the brainstem and the autonomic nervous system by way of metabolic changes at the level of the mitochondria. This results in illnesses that are "unexplainable" by most practicing physicians.

"This amazing information gives real direction to so many of us that have a wide spectrum of mystery illnesses … The book was a must have. It does not disappoint. I suggest buying a copy for your doctor too!" – Kenneth Hull, Amazon reviewer

"Dr. Marrs' book explained how relevant beriberi (vitamin B1 deficiency) is to our modern Western culture as well as the fact that it's not just a third-world phenomenon; another example of what living a high carb lifestyle does to metabolic function." – Dr. Russell S. Schierling

This book represents the life's work of author Dr. Derrick Lonsdale, along with a recent collaboration by co-author Dr. Chandler Marrs. They write, "Understanding the chemistry that decides health or disease is critical to achieving health. A key component of that chemistry involves thiamine. This book details how to recognize, evaluate, treat, and understand thiamine deficiency. It is a complicated topic, but written for a broad audience."

They tell how thiamine deficiency derails mitochondrial oxidative metabolism, giving rise to the classic disease of beriberi, which in the early stages can be considered the prototype for a set of disorders recognized as dysautonomia. They explain:

  • Today's empty calories can result in clinical effects that lead to misdiagnosis.
  • Biochemical changes are induced by vitamin deficiency, particularly that of thiamine.

"Chandler Marrs and Derrick Lonsdale have written a wonderful, informative, well-researched book on thiamine (vitamin B-1). They cover the history of thiamine deficiency disease (Beriberi), thiamine's importance to the functioning of the autonomic nervous system … I'm hoping the authors will write books on the other B-vitamins because they are masters at covering the essentials and beyond." – Dr. Dean Raffelock

"As a primary care physician, I can attest that the book 'Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition' by Lonsdale and Marrs should be required reading for all physicians. It points out a glaring deficiency in our concept of disease. We all see puzzling clinical presentations that often may be explained by nutritional deficiencies. These clinical puzzles often are manifested in the very young, the very old, patients with multisystem chronic diseases, and the obese who live mostly on high calorie/carbohydrate foods … Patients with these micronutrient deficiencies often present with multisystem complaints and findings, usually manifested by disease in the brain, autonomic nervous system, and heart." – Dr. Edward Manring

"I am so grateful to have this science-based text supporting the vanguard of natural healing. The truth is that we are getting sick in more and more complex ways, and dysautonomia is emblematic of the ways in which our bodies are struggling in the setting of malnutrition and toxic burden. This text is clinically relevant, evidence-based, and entirely readable. In fact, a deep desire to contribute to the healing of 'mysteriously' sick patients comes through in the tenor of this writing. For clinicians and struggling patients alike, this text is a one-of-a-kind essential resource on the newest biology of healing." – Dr. Kelly Brogan

"As a patient, this book has really opened my eyes. For over two years now, I've suffered from debilitating symptoms due an adverse drug reaction to metronidazole (aka, Flagyl). These symptoms mysteriously wax and wane … I've discovered the hard way that doctors don't believe in adverse drug reactions; not only will they not treat the condition, they won't acknowledge it exists … Thank you, Dr. Marrs and Lonsdale for all the hard work and dedication to give us this knowledge! Research like yours saves lives!" – Erin, Amazon reviewer

This book is a godsend, it addresses many specific ailments that have accumulated because of B1 deficiency, now I have a scientific reference tool to aid in my healing. This book presents how high sugar consumption is creating nutritional deficiencies that are breaking down mitochondria function. The importance of B1 is poorly understood by well-meaning doctors (even integrative doctors) that simply do not have comprehensive training in nutrients." – Jean, Amazon reviewer

Watch the video book trailer at:    

About the Authors:

Dr. Derrick Lonsdale was educated in England, graduating from London University with the degree MB BS. After National Service in the RAF as a medical officer, he became a family physician under the National Health Service. Dr. Lonsdale immigrated to Canada in 1957, and in 1960 was accepted as a pediatric resident at Cleveland Clinic in Ohio. In 1962, he was appointed to the pediatric staff, where his clinical research led to uncovering the connections between thiamin metabolism and metabolic brain disease. Before retirement, the author was a Fellow of the American College of nutrition and a Certified Nutrition Specialist.

Dr. Chandler Marrs received a BA in philosophy and then spent many years in the tech industry before returning to academia for an MS in clinical psychology and an MA and Ph.D. in experimental psychology with an emphasis in neuroendocrinology. Recognizing the lack of women's health and hormone research, Dr. Marrs founded Lucine Health Sciences, a health research and media company that publishes the online journal Hormones Matter and conducts post-market, direct-to-patient medication safety, and efficacy studies.

The informative new book THIAMINE DEFICIENCY DISEASE, DYSAUTONOMIA, AND HIGH CALORIE MALNUTRITION: 1ST EDITION (ISBN softcover: 978-0-128103-87-6, $99.95; Kindle $79.96; Rental $49.98) is now available and can be ordered through the publisher Academic Press website: or at or


SOURCE Derrick Lonsdale and Chandler Marrs

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