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ZyGEM Launches prepGEM(TM) and forensicGEM(TM) DNA Extraction Products for Forensic, Research and Animal Health Applications

Wednesday, February 27, 2008 General News J E 4
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SOLANA BEACH, Calif., Feb. 26 ZyGEM Corp. Ltd., a leadingprovider of advanced enzymatic tools for life sciences applications, todayannounced the launch of its newly extended prepGEM(TM) and forensicGEM(TM)range of reagent kits for DNA extraction. These innovative products are nowavailable in a wide variety of formats tailored for specific applications andtypes of samples. Based on ZyGEM's proprietary enzyme technology, thesereagent kits represent a significant advance in DNA sample preparation forhuman and animal genotyping and other nucleic acid-based testing and analysis.ZyGEM also announced the launch today of its enhanced website athttp://www.zygem.com.

The prepGEM(TM) and forensicGEM(TM) families of kits leverage the uniqueproperties of ZyGEM's thermophilic enzymes to conduct DNA extraction in asingle closed tube. As a result of this unique approach, prepGEM(TM) andforensicGEM(TM) kits are easy and fast to use. They simplify laboratoryworkflow, minimizing the opportunity for sample contamination and error whilereducing costs. They are flexible, making it possible to automate sampleprocessing using almost any off-the-shelf robotic system. The kits are non-toxic and provide robust, reliable and consistent downstream analytic results.Using these kits, researchers can prepare samples up to three times fasterthan with existing products-the entire process from sample extraction upthrough DNA amplification can be accomplished in just 20 minutes with nohands-on attention required.

prepGEM(TM) and forensicGEM(TM) kits provide benefits that areparticularly valuable for their respective customers. For prepGEM(TM)customers, the ability to obtain DNA that is usable without furtherpurification for most PCR-based downstream applications is an importantadvantage, as is the fact that the kits can be used with almost any liquidhandling system and by workers of varying skill levels. prepGEM(TM)'s rapidresults and low cost are important to customers in both industry and researchsettings.

"The identification of insects on our export produce is critical as manyof our overseas markets will not accept produce if it is contaminated," saidDr. Richard Newcomb, Science Leader, Molecular Olfaction at Hort Research, TheHorticulture and Food Research Institute of New Zealand. "The rapididentification of these insect species is essential so that produce can besent without delay. Our researchers have been using ZyGEM's prepGEM(TM) torapidly extract DNA for PCR-based diagnostics of insect species, especiallyscale insects that are sometimes found on kiwifruit. In a one-step process,insect scale is loaded into multi-well plates and the ZyGEM enzyme added.After incubation and heat treatment, an aliquot from each well is transferredfor PCR identification. This simple method saves time and money andcontributes to maintaining important markets for New Zealand's horticulturalexports."

forensicGEM(TM) kits provide a proven and efficient way to prepare DNA forforensic analysis, even from challenging samples. Customers particularlyappreciate the fact that the closed-tube system ensures sample integrity byminimizing the risk of contamination. The demanding requirements of forensicDNA analysis are addressed by the expanded range of forensicGEM(TM) kits thatare specifically designed to work with a variety of difficult samples withoutthe need for further purification. The ease of automation and lower costs offorensicGEM(TM) kits are important features for forensic customers who managehigh volume analyses for database applications. forensicGEM(TM) kits havebeen extensively tested and validated and are proven in routine use in actualforensic labs.

"The unique properties of our proprietary EA1 protease, the key ingredientin the forensicGEM(TM) and prepGEM(TM) family of kits, make possible this costeffective and flexible solution for researchers performing a
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