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Webcast Alert: Isis Pharmaceuticals Hosts Expert Panel Conference Call to Discuss Mipomersen Data Presented at the ESC Congress 2010

Tuesday, August 31, 2010 Drug News J E 4
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CARLSBAD, Calif., Aug. 30 Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announces the following webcast:

If you are unable to participate during the live event, a replay of the webcast will be available for a limited time at www.isispharm.com.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 23 drugs in development. Isis' drug development programs are focused on treating cardiovascular, metabolic, and severe neurodegenerative diseases and cancer. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microRNA therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,600 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.

Data from mipomersen Phase 3 trial in heFH patients presented at What: ESC When: Wednesday, September 1, 2010 at 4:00 p.m. ET / 1:00 p.m. PT Where: www.isispharm.com How: Live on the Internet. Simply log onto our Web site listed above.

SOURCE Isis Pharmaceuticals, Inc.
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