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Roche Extends Tender Offer for Ventana

Wednesday, August 22, 2007 General News J E 4
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BASEL, Switzerland, Aug. 21 Roche (SWX: ROG.VX; RO.S), aworld-leading healthcare provider of pharmaceuticals and diagnostics,announced today that it has extended its offer to acquire all of theoutstanding common shares of Ventana Medical Systems, Inc. (Nasdaq: VMSI) to5:00 p.m., New York City time on Thursday, September 20, 2007. The tenderoffer was previously scheduled to expire at 5:00 p.m., New York City time, onAugust 23, 2007. All other terms and conditions of the tender offer remainunchanged. As of the close of business on August 21, 2007, approximately13,430 shares have been tendered pursuant to the offer.

On June 27, 2007, Roche commenced a tender offer to acquire all of theoutstanding common shares of Ventana for $75.00 per share in cash. This pricerepresents a 44% premium to Ventana's close of $51.95 on June 22, 2007 (thelast trading day prior to the announcement of Roche's offer) and a 55% premiumto its three-month average as of the same date of $48.30.

Greenhill & Co. and Citi are acting as financial advisors to Roche andDavis Polk & Wardwell is acting as legal counsel.

About Roche

Headquartered in Basel, Switzerland, Roche is one of the world's leadingresearch-focused healthcare groups in the fields of pharmaceuticals anddiagnostics. As the world's biggest biotech company and an innovator ofproducts and services for the early detection, prevention, diagnosis andtreatment of diseases, the Group contributes on a broad range of fronts toimproving people's health and quality of life. Roche is the world leader inin-vitro diagnostics and drugs for cancer and transplantation, a market leaderin virology and active in other major therapeutic areas such as autoimmunediseases, inflammation, metabolism and central nervous system. In 2006 salesby the Pharmaceuticals Division totaled CHF 33.3 billion, and the DiagnosticsDivision posted sales of CHF 8.7 billion. Roche employs roughly 75,000 peopleworldwide and has R&D agreements and strategic alliances with numerouspartners, including majority ownership interests in Genentech and Chugai.

Roche's Diagnostics Division offers a uniquely broad product portfolio andsupplies a wide array of innovative testing products and services toresearchers, physicians, patients, hospitals and laboratories world-wide.

Roche commenced operations in the U.S. over 100 years ago and theseoperations include research and development centers that conduct leading-edgework in advancing disease detection and treatment. Our diagnostics andpharmaceuticals businesses in the U.S. employ more than 20,000 people andgenerate approximately $10 billion in sales (including Genentech), accountingfor about 40% of the Roche Group's global annual revenues.

Further information

- All documents on the offer to Ventana's shareholders:http://www.roche.com/info070625

CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS

THIS DOCUMENT CONTAINS CERTAIN FORWARD-LOOKING STATEMENTS. THESE FORWARD-LOOKING STATEMENTS MAY BE IDENTIFIED BY WORDS SUCH AS 'BELIEVES', 'EXPECTS','ANTICIPATES', 'PROJECTS', 'INTENDS', 'SHOULD', 'SEEKS', 'ESTIMATES', 'FUTURE'OR SIMILAR EXPRESSIONS OR BY DISCUSSION OF, AMONG OTHER THINGS, STRATEGY,GOALS, PLANS OR INTENTIONS. VARIOUS FACTORS MAY CAUSE ACTUAL RESULTS TO DIFFERMATERIALLY IN THE FUTURE FROM THOSE REFLECTED IN FORWARD-LOOKING STATEMENTSCONTAINED IN THIS DOCUMENT, AMONG OTHERS: (1) PRICING AND PRODUCT INITIATIVESOF COMPETITORS; (2) LEGISLATIVE AND REGULATORY DEVELOPMENTS AND ECONOMICCONDITIONS; (3) DELAY OR INABILITY IN OBTAINING REGULATORY APPROVALS ORBRINGING PRODUCTS TO MARKET; (4) FLUCTUATIONS IN CURRENCY EXCHANGE RATES ANDGENERAL FINANCIAL MARKET CONDITIONS; (5) UNCERTAINTIES IN THE DISCOVERY,DEVELOPMENT OR MARKETING OF NEW PRODUCTS OR NEW USES OF EXISTING PRODUCTS,INCLUDING WITHOUT LIMITATION NEGATIVE RESULTS OF CLINICAL TRIALS OR RESEARCHPR
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