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Pharmasset Announces Consummation of $24.18 Million Registered Direct Offering of Common Stock

Wednesday, July 23, 2008 General News
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PRINCETON, N.J., July 22 Pharmasset, Inc.(Nasdaq: VRUS) announced today that it has consummated the previouslyannounced registered direct offering of 1,450,000 shares of its common stockto a select group of institutional investors at $17.85 per share. The offeringresulted in net proceeds of approximately $24.18 million, after deductingplacement agents' fees and estimated offering expenses. Morgan Stanley & Co.Incorporated, Canaccord Adams Inc., Cowen and Company, LLC and Leerink SwannLLC served as placement agents for the offering and Morgan Stanley acted aslead manager. In addition, Trout Capital LLC acted as financial advisor toPharmasset.
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The shares described above were offered by Pharmasset pursuant to aregistration statement previously filed and declared effective by theSecurities and Exchange Commission on June 26, 2008.
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This press release shall not constitute an offer to sell or thesolicitation of an offer to buy any of the securities described herein, norshall there be any sale of these securities in any state or jurisdiction inwhich such offer, solicitation or sale would be unlawful prior to registrationor qualification under the securities laws of any such state or jurisdiction.Copies of the prospectus supplement and accompanying base prospectus relatingto this offering may be obtained at the SEC's website at http://www.sec.gov orby calling Morgan Stanley & Co. Incorporated, toll free, at 1-866-718-1649.

About Pharmasset

Pharmasset is a clinical-stage pharmaceutical company committed todiscovering, developing and commercializing novel drugs to treat viralinfections. Pharmasset's primary focus is on the development of oraltherapeutics for the treatment of hepatitis B virus (HBV), hepatitis C virus(HCV) and human immunodeficiency virus (HIV).

Pharmasset is currently developing three product candidates. Clevudine,for the treatment of chronic HBV infection, is enrolling Phase 3 clinicaltrials for registration in North, Central and South America and Europe.Clevudine is already approved for HBV in South Korea and marketed by BukwangPharmaceuticals in South Korea under the brand name Levovir. R7128, an oraltreatment for chronic HCV infection, is in a Phase 1/2 clinical trial incombination with Pegasys(R) plus Copegus(R) through a strategic collaborationwith Roche. Racivir, which is being developed for the treatment of HIV incombination with other approved HIV drugs, has completed a Phase 2 clinicaltrial.

Forward-Looking Statements

Pharmasset "Safe Harbor" Statement under the Private Securities LitigationReform Act of 1995: Statements in this press release regarding our businessthat are not historical facts are "forward-looking statements" that involverisks and uncertainties, including without limitation, the risk that adverseevents could cause the cessation or delay of any of the ongoing or plannedclinical trials and/or our development of our product candidates, the riskthat the results of previously conducted studies involving our productcandidates will not be repeated or observed in ongoing or future studiesinvolving our product candidates, the risk that our collaboration with Rochewill not continue or will not be successful and the risk that any one or moreof our product candidates will not be successfully developed andcommercialized. For a discussion of these risks and uncertainties, any ofwhich could cause our actual results to differ from those contained in theforward-looking statements, see the section of our Annual Report on Form 10-Kfor the fiscal year ended September 30, 2007 filed with the Securities andExchange Commission entitled "Risk Factors" and discussions of potential risksand uncertainties in our subsequent filings with the Securities and ExchangeCommission.Pegasys(R) and Copegus(R) are registered trademarks of Roche. Contact Kurt Leutzinger Chief Financial Officer kurt
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