Medindia

X

Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois

Monday, June 2, 2008 General News J E 4
Advertisement
NEW YORK, June 2 Keryx Biopharmaceuticals, Inc.(Nasdaq: KERX) today announced that abstracts related to KRX-0401 (Perifosine)have been selected for both poster presentation and publication during theAmerican Society of Clinical Oncology Meeting currently taking place inChicago, Illinois (May 31 - June 3, 2008).

Copies of these abstracts, which highlight the observed clinical andpreclinical activity of KRX-0401 as a single agent and in combination withnovel agents are currently available and can be viewed on-line through theASCO website: http://www.asco.org/ASCO/Abstracts+%26+Virtual+Meeting/Abstracts

The following abstract will be available for viewing during the postersession taking place tomorrow, Tuesday, June 3, 2008, from 8:00am-12:00pm:

Abstract 8546: A Phase 2 trial of the novel oral Akt inhibitor perifosinein relapsed and/or refractory Waldenstrom macroglobulinemia

Investigators: Irene M. Ghobrial, X. Leleu, N. Rubin, R. Leduc, S. Chuma,M. Nelson, P. G. Richardson, S. P. Treon, K. C. Anderson

Following the poster session, lead investigator, Dr. Irene Ghobrial, willbe presenting the abstract during the Lymphoma and Plasma Cell DisordersPoster Discussion Forum, scheduled to take place at 12:00pm in Room E450a.

Additionally, the following abstracts have been accepted for publicationonly:

Abstract 16024: Phase 1 multicenter trial of perifosine in combinationwith sorafenib for patients with advanced cancers including renal cellcarcinoma.

Investigators: M. T. Schreeder, R. A. Figlin, J. J. Stephenson, L. Campos,S. P. Chawla, D. R. Spigel, A. Spira

Abstract 14565: Phase 1 report from a multicenter trial of perifosine(PERI) + sunitinib (SUT) in patients with advanced cancers including renalcell carcinoma.

Investigators: P. Allerton, B. Ebrahimi, M. T. Schreeder, P. Kaiser, S. P.Chawla

Abstract 16083: Preclinical rationale for combination targeted therapy inadvanced clear cell renal cell carcinoma (RCC): Abrogation ofrapamycin-mediated induction of AKT phosphorylation by perifosine.

Investigators: W. S. Holland, P. C. Mack, D. R. Gandara, P. N. Lara

KRX-0401 (Perifosine) Mechanism of Action and Profile

KRX-0401 (Perifosine) is a novel, potentially first-in-class, oralanti-cancer agent that modulates Akt and a number of other key signaltransduction pathways, including the JNK and MAPK pathways, all of which arepathways associated with programmed cell death, cell growth, celldifferentiation and cell survival. The effects of perifosine on Akt are ofparticular interest because of the importance of this pathway in thedevelopment of most cancers, the evidence that it is often activated in tumorsthat are resistant to other forms of anticancer therapy, and the difficultyencountered thus far in the discovery of drugs that will inhibit this pathwaywithout causing excessive toxicity. High levels of activated Akt (pAkt) areseen frequently in many types of cancer and have been correlated with poorprognosis in patients with soft-tissue sarcoma, gastric, hepatocellular,endometrial, prostate, renal cell, head and neck cancers and hematologicalmalignancies, as well as glioblastoma. The majority of tumors expressing highlevels of pAkt were high-grade, advanced stage or had other featuresassociated with poor prognosis. High pAkt is often seen in tumors that areresistant to conventional cancer treatments, including radiotherapy,chemotherapy, endocrine therapy, and especially therapy with some of the newerbiologicals.

To date, over 1,700 patients have been treated with KRX-0401 in trialsconducted both in the United States and Europe. Its safety profile isdistinctly different from that of most cytotoxic agents. It does not appear tocause myelosuppression (depression of the immune system that may lead to lifethreatening infections), thrombocytopenia
Advertisement


Advertisement

You May Also Like

Advertisement
View All

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
I agree to the terms and conditions
s
Acuo Technologies(R), Developers of the DICOM Serv...
S
Rita's Paper Lemon Program Gives Childhood Cancer ...