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InterMune Provides Program Update and 2010 Milestones for RG7227 (ITMN-191)

Tuesday, January 12, 2010 General News J E 4
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Milestones and Key Events

Expected Date

Un-blinded rapid virologic response (RVR) and early virologic response (EVR) data from the on-going Phase 2b study of RG7227 plus SOC (un-boosted 12-week regimens)

Late Q1 or early Q2 2010 (updated guidance with additional data reported)

Initiation of INFORM-2 program (ritonavir-boosted RG7227 plus RG7128)

Q1 2010: Timing subject to change due to integration of new ritonavir boosting strategy

Initiation of longer duration DAA study to evaluate SVR (ritonavir boosted)

Q2 2010: Timing subject to change due to integration of new ritonavir boosting strategy

Initiation of Phase 2b study of ritonavir-boosted RG7227 plus SOC

Q3 2010 (new study)

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