Symptoms of bloating, belching, nausea, vomiting, diarrhea and acidic taste in the mouth are commonly reported as indigestion.
Conditions in which indigestion is present are:
- Gastroesophageal Reflux Disease (GERD) It is a condition in which there is reflux of stomach contents which are acidic in nature into the esophagus causing heart burn, difficulty swallowing, dry cough, regurgitation of food and lump-like feeling in the throat. Risk of developing GERD increases with obesity, pregnancy, hiatal hernia, smoking, diabetes, asthma and scleroderma.
- Gastritis It is the inflammation of the stomach lining. It can be caused due to infections (Helicobacter pylori), stress, consumption of alcohol, smoking, use of NSAIDs, reflux of bile into the stomach, allergies or immune conditions and exposure to radiation. Common symptoms include pain and discomfort in the upper abdomen, loss of appetite, weight loss, nausea, vomiting and melena (blood in stools). Helicobacter pylori infection is often treated with a course that includes two antibiotics, which are usually amoxicillin and clarithromycin. H2 blockers, proton pump inhibitors and bismuth subsalicylate are often used for relief from symptoms.
- Peptic Ulcer Disease It is an open sore or raw area in the lining of the stomach or the first part of the duodenum. It can be caused by Helicobacter pylori infection. A rare condition called as Zollinger Ellison syndrome can cause multiple ulcers in the stomach and duodenum. Incidence of peptic ulcers is raised with consumption of alcohol, smoking, stress, use of NSAIDs and radiation treatments. Feeling of fullness in the stomach, pain and discomfort in the upper abdomen, nausea, vomiting, tarry stools, weight loss and fatigue are common symptoms. Ulcers can complicate and cause perforation and bleeding.
- Celiac Disease It is an autoimmune condition that affects the small intestine when foods containing gluten are consumed. Gluten is a protein found in wheat, rye and barley. Common symptoms found with this condition are abdominal pain, bloating, weight loss, pale foul-smelling stools, failure to thrive, diarrhea and skin rash. Iron deficiency anemia and deficiency of copper, zinc, selenium, calcium and vitamin D are often present due to malabsorption.
- Gallstones These are hard structures formed in the gall bladder causing obstruction of the bile duct or inflammation of the gall bladder. The stones could be pigment stones or cholesterol stones or mixed stones. The condition affects women more often than men. Obesity and age over 40 years increase the risk of developing gallstones. It presents with right upper abdominal pain that is constant, either sharp or dull, yellowish skin and eyes, fever, clay colored stools, nausea and vomiting.
- Liver Disease The liver secretes enzymes that are necessary for the digestion of food, particularly fat. Thus, diseases affecting the liver often cause indigestion. Symptoms of liver disease include abdominal pain or discomfort and jaundice. Conditions affecting the liver include acute hepatitis, chronic hepatitis, cirrhosis of the liver and liver cancer.
- Pancreatitis It is the inflammation of the pancreas leading to damage and loss of function of the pancreas. It causes problems with digestion and can be acute or chronic. It is often caused due to alcoholism, obesity, gallstones, procedures in the abdomen like ERCP, infections, smoking, cystic fibrosis, high calcium levels and tumors of the pancreas. Common symptoms include upper abdominal pain that radiates to the back and is often worse after eating, vomiting, tenderness in the abdomen, nausea, fatty foul-smelling stools and unintentional weight loss.
- Intestinal Obstruction It occurs due to physical obstruction of either the small or large intestine. This can happen due to diverticulitis, adhesions, hernia, intussusceptions, volvulus or tumors. Intestinal obstruction can also happen due to functional disturbances without any physical obstruction. It is also called as paralytic ileus. Gastroenteritis, electrolyte and mineral imbalances, mesenteric ischemia, post-abdominal surgery complications, kidney or lung disease and use of certain drugs like narcotics can cause paralytic ileus. It presents with abdominal distension with on and off cramping pain, diarrhea, constipation, vomiting, inability to pass gas and bad breath.
- Stomach Cancer It can affect any part of the stomach namely cardia, fundus, body, antrum and pylorus. There are different types of stomach cancer like adenocarcinoma, gastrointestinal stromal tumor, lymphoma and carcinoid tumor. It commonly presents with upper abdominal pain and discomfort after eating, blood in stools, fatigue, loss of appetite, vomiting with or without blood, and unintentional weight loss. Cancer of the esophagus may also be associated with dyspepsia. In addition, it may be associated with bleeding while coughing and difficulty with swallowing.
- Intestinal Ischemia It is a condition that develops due to inadequate blood supply to small or large or both the intestines. It can be acute or chronic. Common symptoms of this condition are sudden cramping abdominal pain, swelling and tenderness in the abdomen, urgency to defecate, vomiting, bloating, fever, nausea and bloody stools.
- Irritable Bowel Syndrome It is a condition where the patient does not have any obvious pathology but suffers from symptoms like diarrhea or constipation. Stress and diet can aggravate existing irritable bowel disease.
- Inflammatory Bowel Disease It includes Crohns disease and regional ileitis. Family history of inflammatory bowel disease and faulty immune response play a role in the occurrence of this condition. It presents with diarrhea, blood in stools, fever, abdominal cramping pain, fatigue, weight loss and loss of appetite.
- Infection Viral (rotavirus, norovirus), bacterial (E.coli, Campylobacter jejuni) and parasitic (Giardia lamblia) infections can cause gastroenteritis. Gastroenteritis presents with diarrhea, vomiting, abdominal cramping, pain, fatigue, headache, bloody stools and dehydration.
- Intestinal Tuberculosis It is commonly caused by Mycobacterium tuberculosis. It is caused due to ingestion of infected milk or food, swallowing of sputum in active pulmonary tuberculosis, spread from active pulmonary focus via blood stream and contagious spread from infected fallopian tubes or mesenteric lymph nodes. The ileocecal region is most commonly affected. Abdominal pain with distension, weight loss, diarrhea or constipation, fever and loss of appetite are common symptoms with intestinal tuberculosis.
- Malabsorption Syndrome It is a condition in which small intestine is unable to absorb nutrients from the food consumed. Malabsorption occurs due to underlying conditions like celiac disease, lactose intolerance, short bowel syndrome, Whipple disease, genetic conditions and use of certain drugs.
- Lactose Intolerance / Food Allergy It is a condition in which people experience indigestion, bloating, excess gas formation and diarrhea after consumption of milk or milk products. Milk contains a sugar called lactose. The small intestine produces an enzyme called lactase, which breaks the sugar lactose into glucose and galactose for absorption into the blood stream. Lactose intolerance happens either due to lactase deficiency or lactose malabsorption. Allergies to foods like peanuts, milk etc. are quite common especially in children and can cause symptoms of indigestion in these individuals.
- Systemic Illness Some conditions that cause hormonal or other problems in the body may also cause indigestion. These conditions include anxiety, thyroid disorders, diabetes, other hormonal disorders and heart failure. Therefore, in a person complaining of indigestion, a general body examination is also necessary to rule out other conditions that may cause indigestion.