Clinical manifestations of severe malaria are -
- Decrease in blood platelets or Thrombocytopenia
- Cardiovascular collapse
- Kidney failure
- Low blood glucose
- More severe manifestations in Immuno-suppressed patients.
- Malarial relapse of P. vivax and P. ovale infections occurs in patients who have recovered from illness and may suffer from several relapses which may occur after months or even years after earlier infections.
- Malarial drugs prevent symptoms of malaria but do not prevent relapses of infection caused by strains of the parasite that have a persistent liver phase.
- Relapses occur due to reactivation of dormant parasites which are present in the liver.
- Complete treatment to avoid relapse attack during the vary first infection can help in avoiding relapses.