Latest Publications and Research on Dengue / Dengue Hemorrhagic Fever

Ann Palliat Med    

A survey of clinical and laboratory characteristics of dengue fever epidemic from 2014 to 2018 in Guangzhou, China.

Chen D, Zhang Y, Wu X, Wu J, Gong F, Qiao L, Li L, Wang C

In 2014, a serious dengue outbreak occurred in Guangzhou, South China. In this study, the clinical and laboratory characteristics of dengue fever (DF)... Read More

Source: PubMed


Epidemics    

Temperature-dependent variation in the extrinsic incubation period elevates the risk of vector-borne disease emergence.

Kamiya T, Greischar MA, Wadhawan K, Gilbert B, Paaijmans K, Mideo N

Identifying ecological drivers of disease transmission is central to understanding disease risks. For vector-borne diseases, temperature is a major de... Read More

Source: PubMed

PLoS ONE    

High prevalence of Phasi Charoen-like virus from wild-caught Aedes aegypti in Grenada, W.I. as revealed by metagenomic analysis.

Ramos-Nino ME, Fitzpatrick DM, Tighe S, Eckstrom KM, Hattaway LM, Hsueh AN, Stone DM, Dragon J, Cheetham S

Arboviruses cause diseases of significant global health concerns. Interactions between mosquitoes and their microbiota as well as the important role o... Read More

Source: PubMed

East. Mediterr. Health J.    

Knockdown resistance mutations contributing to pyrethroid resistance in Aedes aegypti population, Saudi Arabia.

Dafalla O, Alsheikh A, Mohammed W, Shrwani K, Alsheikh F, Hobani Y, Noureldin E

Dengue is endemic in Saudi Arabia especially in Jeddah, Makkah, Asir, and Jazan areas where pyrethroids are widely used to control the vector, Aedes a... Read More

Source: PubMed

East. Mediterr. Health J.    

Role of climatic factors in the incidence of dengue in Port Sudan City, Sudan.

Noureldin E, Shaffer L

Dengue fever outbreaks have occurred in Port Sudan City, Sudan, during the last 2 decades. Climatic factors may play a role in dengue incidence.... Read More

Source: PubMed

Comments

yousufmohammad Thursday, August 26, 2010

please inform if age is 54 women, High blood pressure and chronic disease, She has Fever and body pain.She is in ICU for three days.is it advised to get her discharged.Platelet count 1 lac. How severe dengue can be in her condition?
As my Mother in ICU>Please Reply

Awaami Sunday, November 13, 2011

Dear Yousaf,with Hypertension,another chronic disease,and age above 50,the afebrile period is significant,the patient should be advised about the warning signs for plasma leakaga,i.e, the reduced BP,or reduced pulse pressure[the difference between the upper-systolic and lower-diastolic one,e.g. if it comes down to 100/90.the increased capillary refilling time, the tender liver,and or hemmhorages,reduced urinary output,blood in vomiting,altered mentation,increasing respiratory disconfort. All these may indicate her transition towards shock,which is actually far more important than platelts,particularly in absence of internal or external bleeding . Observe your patient for all this,and then decide about discharge. Regards . P-dopp Peoples Doctors @ facebook.

Tewari55 Friday, July 23, 2010

The platelet count is not the only important determinant of bleeding.


Indications for blood/platelet transfusion as recommended in clinical practice guidelines are:

In cases with significant clinical bleeding, which require blood transfusion. Usually bleeding is > 10% of total blood volume (> 6-8 ml/kg of ideal body weight)
In adults with underlying hypertension or coronary heart diseases and platelet 1.3-1.5, which is the result of liver failure: Major contributing factor for massive bleeding.
There is no evidence to support the use of blood components such as platelet concentrates, fresh frozen plasma or cryoprecipitate. Its use could contribute to fluid overload.

Important instructions for treatment of DHF as per WHO/SEARO guidelines:

If the patient’s condition becomes worse despite giving 20ml/kg/hr crystalloid solution for one hour, replace crystalloid solution with colloid solution such as Dextran or Plasma. As soon as improvement occurs, replace with crystalloid.


In case of severe bleeding; give blood transfusion @ 20ml/kg for two hours. Then give crystalloid IV fluids @ 10 ml/kg/hr for a short time (30 - 60 minutes) and later reduce the speed.


If hematocrit falls, give blood transfusion 10 ml/kg and then give crystalloid IV fluids at the rate of 10 ml/kg/hr. The volume of blood administered should be just enough to raise the red blood cell concentration to normal.

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