About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Zollinger–Ellison Syndrome

Last Updated on Dec 23, 2021
Font : A-A+

About

Zollinger–Ellison syndrome results from increased acid secretion due to the presence of a tumor called gastrinoma.

Advertisement

Zollinger–Ellison syndrome is a condition in which the patient suffers from ulcers in the upper digestive tract (that do not respond to medications), excessive gastric acid secretion, and diarrhea.

Zollinger-Ellison Syndrome

Zollinger–Ellison syndrome is caused by a tumor called a gastrinoma. A gastrinoma secretes gastrin, a hormone that stimulates gastric acid secretion. Gastrinomas may arise from the duodenum (the first part of the small intestine), the pancreas, and occasionally from other parts like the ovary, liver, and the stomach. They usually affect people between 30 and 50 years of age. Men are more commonly affected than women. In some cases, gastrinomas may be a part of a syndrome called Multiple Endocrine Neoplasia Type 1. In this syndrome, the patient suffers from multiple tumors like pancreatic and pituitary tumors, as well as hyperparathyroidism.

Advertisement

Gastrinomas release a hormone called gastrin. Gastrin acts on the stomach lining and stimulates it to release excess acid. It also increases the number of acid-secreting cells lining the stomach. The increased acid secretion results in inflammation and ulcers in the stomach and lower food pipe, and diarrhea.

Tests used to diagnose Zollinger–Ellison syndrome include blood tests to check for gastrin levels, gastric acid levels and secretin test to check for acid hypersecretion. Imaging studies are used to localize the tumor.

Acid-suppressive drugs are used in the treatment of Zollinger–Ellison syndrome to prevent the adverse effects of the excess acid on the stomach lining. The gastrinoma maybe surgically removed to prevent spread of the tumor.

References:

  1. Harrison’s Principles of Internal Medicine 17th edition.
  2. Tomassetti P, et al. Treatment of Zollinger-Ellison Syndrome. World J Gastroenterol 2005;11(35):5423–5432.

Latest Publications and Research on Zollinger–Ellison Syndrome

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Dr. Simi Paknikar. (2021, December 23). Zollinger–Ellison Syndrome - Causes - Symptoms - Diagnosis - Treatment. Medindia. Retrieved on May 25, 2022 from https://www.medindia.net/patients/patientinfo/zollinger-ellison-syndrome.htm.

  • MLA

    Dr. Simi Paknikar. "Zollinger–Ellison Syndrome - Causes - Symptoms - Diagnosis - Treatment". Medindia. May 25, 2022. <https://www.medindia.net/patients/patientinfo/zollinger-ellison-syndrome.htm>.

  • Chicago

    Dr. Simi Paknikar. "Zollinger–Ellison Syndrome - Causes - Symptoms - Diagnosis - Treatment". Medindia. https://www.medindia.net/patients/patientinfo/zollinger-ellison-syndrome.htm. (accessed May 25, 2022).

  • Harvard

    Dr. Simi Paknikar. 2021. Zollinger–Ellison Syndrome - Causes - Symptoms - Diagnosis - Treatment. Medindia, viewed May 25, 2022, https://www.medindia.net/patients/patientinfo/zollinger-ellison-syndrome.htm.


Do you wish to consult a Gastroenterologist for your problem? Ask your question

Dr. Deshmukh Parag
Dr. Deshmukh Parag
MBBS, MD, DNB, IDCCM, CCEBDM
5 years experience
Teleconsult Now View Profile
Dr. Pankaj Kumar
Dr. Pankaj Kumar
MBBS, MD, DM Gastroenterology
10 years experience
Teleconsult Now View Profile
View All

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Advertisement
Health Topics A - Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z



    Advertisement
    What's New on Medindia
    Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
    Seasonal Allergy Medications
    How to Choose the Best Eczema-Friendly Moisturizer for Children?
    View all
    Advertisement

    Medindia Newsletters Subscribe to our Free Newsletters!
    Terms & Conditions and Privacy Policy.

    Most Popular on Medindia

    Sinopril (2mg) (Lacidipine) Diaphragmatic Hernia Drug - Food Interactions Calculate Ideal Weight for Infants Sanatogen Daily Calorie Requirements Find a Doctor How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care Selfie Addiction Calculator

    Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

    © All Rights Reserved 1997 - 2022

    This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use