von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from birth and affects both sexes. It occurs due to a defect in the genes. Autosomal dominant means that even if one parent has the abnormal gene, you could inherit the disease. vWD has a prevalence of 1 to 3% of the population and has no ethnic predominance. The disease was first described by Erik Adolf von Willebrand in 1926.
The gene for von Willebrand factor is on the short arm of chromosome 12.
Types of von Willebrand's Disease
There are three types of Hereditary vWD:
Type1: Type1 vWF is the mildest and most common form of VWD. Type 1 vWD accounts for 75 to 80% of patients and is inherited predominantly via an autosomal dominant mode.
Type3: This is the most severe form of von Willebrand disease. There is almost complete absence of circulating vWF. It is an exceedingly rare variant that occurs in 1 of every 1 million individuals
- Wilms tumor
- Congenital heart disease
- Systemic lupus erythematosus (SLE)
- Seizure disorders treated with valproic acid
Latest Publications and Research on von Willebrand DiseaseThe role of ADAMTS13 testing in the diagnosis and management of thrombotic microangiopathies and thrombosis. - Published by PubMed
Aortic stenosis and anemia with an update on approaches to managing angiodysplasia in 2018. - Published by PubMed
Platelet function tests: A 5-year audit of platelet function tests done for bleeding disorders in a tertiary care center of a developing country. - Published by PubMed
Management of pregnancy and emergency caesarean delivery in a patient with type IIB von Willebrand disease and severe preeclampsia: A case report and literature review. - Published by PubMed
The Use of Phage Display and Yeast Based Expression System for the Development of a Von Willebrand Factor Propeptide Assay: Development of a Von Willebrand Factor Propeptide Assay. - Published by PubMed