ďA new branch of medicine will develop that attempts to change the course of chronic disease and in many instances will regenerate tired and failing organ systems.Ē Leland Kaiser
The elixir of life may still be evading us but the human ďspare parts industryĒ is waiting in the wings to sustain manís desire for eternity.
The science of tissue engineering is the core of an emerging branch of medicine, known as regenerative medicine, which is expected to revolutionalize manís health and hugely improve his quality of life.
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind -boggling implications if fully potentialized.
Tissue engineering, and the associated field of
The first of the experiments related to
They sprinkled chondrocytes with collagen in scaffolds with 3D pores and co cultured the two in a bioreactors. Chondrocytes are mesenchyme-derived stem cells with a potential to grow into cartilage.
The scaffold was biodegradable; the chondrocytes eventually replaced the collagen and the scientists successfully grew the tissue of an outer ear which was successfully grafted and grown on the back of a laboratory mouse.
This type of tissue culturing is also known as 3D cell culture or histo-cellular culture.
Later experiments revealed that epidermal stem cells derived from the foreskin can be grown into keratinocytes and those from the dermis can be grown into fibro blasts. These cells can then be grown into the required tissue, mainly for skin grafts. This is employed in the fast- growing field of skin
Anthony Atala, MD in 2006 at Wake Forest University had success with growing bladders in the laboratory from patientsí own cells. Cells and muscles from the damaged bladder of a patient was taken and grown on a biodegradable scaffold shaped like a bladder. The lining was then attached to the patientsí existing bladders.
Similarly trachea was grown in 2008 for a 30-year-old lady suffering from tuberculosis. These patients didnít require any drugs to suppress her immune system.
A beating ratís heart was created by researchers at the University of Minnesota, by the same technique.
- Regenerative medicine. Opportunities and challenges: a brief overview - (http://rsif.royalsocietypublishing.org/content/7/Suppl_6/S777.full)
Latest Publications and Research on Tissue Engineering and Regenerative Medicine
- Primary Cilia Mediate Wnt5a/Ŗ-catenin Signaling to Regulate Adipogenic Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Calcium Induction. - Published by PubMed
- Contact-Triggered Lipofection from Multilayer Films Designed as Surfaces for In Situ Transfection Strategies in Tissue Engineering. - Published by PubMed
- Enhanced Efficacy of Immunization with a Foot-and-Mouth Disease Multi-Epitope Subunit Vaccine Using Mannan-Decorated Inulin Microparticles. - Published by PubMed
- Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions. - Published by PubMed
- Wound Healing Promoting Activity of Tonsil-Derived Stem Cells on 5-Fluorouracil-Induced Oral Mucositis Model. - Published by PubMed