What are the Tests for Rheumatoid Arthritis?
An interview with the patient where the patient may complain of:
- Joint pain. Smaller joints are affected in rheumatoid arthritis first, followed by larger joints. The joint involvement is usually symmetrical on both sides of the body
- Morning stiffness
- Joint deformities in later stages
- Swelling and tenderness of the affected joints
- Presence of joint nodules
Imaging tests: They are used to study joint disease. Some of the imaging tests used for rheumatoid arthritis include:
- X-ray: These may not show any changes in the initial stages of rheumatoid arthritis. The joints may show the presence of erosion with reduced joint space and presence of deformity. Features of osteoporosis may be present in the bones adjacent to the affected joints. X-ray is a cheap diagnostic method, but cannot detect very early changes of rheumatoid arthritis.
- Other tests: Other imaging studies like MRI, ultrasound and CT scan can also detect changes in joints in rheumatoid arthritis, but are not used routinely for this purpose.
- Blood tests: Since rheumatoid arthritis is an autoimmune disease, proteins called antibodies can be detected in the blood, which move to the joint, thereby causing arthritis. There are several blood tests that can diagnose the presence of rheumatoid arthritis. The proteins that are looked for in these tests are referred to as markers of the disease. Measurements of several of these markers have been explored for the diagnosis of rheumatoid arthritis. The most commonly used among these are:
- Rheumatoid factor: This is an antibody often present in the blood of patients with rheumatoid arthritis; a positive test in a patient with symptoms of rheumatoid arthritis confirms the diagnosis. A very high level may indicate a more severe disease. However, rheumatoid factor may also be positive in people who do not suffer from rheumatoid arthritis, therefore caution is required while interpreting a result with positive rheumatoid factor.
- Anti-CCP antibodies: Antibodies to cyclic citrullinated peptides are yet another type of antibodies that help in confirming the diagnosis in patients with positive rheumatoid factor. The test is sometimes positive several years before the appearance of symptoms of rheumatoid arthritis.
- Complete Blood counts: A red blood cell count can help to detect anemia, which is often present in patients with rheumatoid arthritis. A white blood cell count may also be used to aid in the diagnosis.
- Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP): These are blood tests that indicate the presence of inflammation in the body. They can also be used to monitor the response of the patient to treatment.
Latest Publications and Research on Tests for Rheumatoid ArthritisA Pilot Randomized Controlled Double-Blind Trial of High- Versus Low-Dose Weekly Folic Acid in People With Rheumatoid Arthritis Receiving Methotrexate. - Published by PubMed
Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. - Published by PubMed
A Useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3. - Published by PubMed
Comparison of latent tuberculosis infection screening strategies before tumor necrosis factor inhibitor treatment in inflammatory arthritis: IGRA-alone versus combination of TST and IGRA. - Published by PubMed
The best cardiovascular risk calculator to predict carotid plaques in rheumatoid arthritis patients. - Published by PubMed