Sleep Med.
Utility of the sleep stage sequence preceding sleep onset REM periods for the diagnosis of narcolepsy: a study in a Japanese cohort.
Kawai R, Watanabe A, Fujita S, Hirose M, Esaki Y, Arakawa C, Iwata N, Kitajima T
The minimum narcolepsy criteria "mean sleep latency (MSL) =8 min and =2 sleep onset rapid eye movement (REM) periods (SOREMPs) on polysomnography (PSG ...
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Source: PubMed
CNS Drugs 2020 Jan 29
Pitolisant: A Review in Narcolepsy with or without Cataplexy.
Lamb YN
Pitolisant (Wakix®), an orally available, first-in-class antagonist/inverse agonist of the histamine 3 receptor, is approved in the EU (as of March 20 ...
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Source: PubMed
Curr Treat Options Neurol
Immunotherapy in Narcolepsy.
Giannoccaro MP, Sallemi G, Liguori R, Plazzi G, Pizza F
Narcolepsy type 1 (NT1) is a chronic and disabling sleep disorder due to the loss of hypocretinergic neurons in the lateral hypothalamus pathophysiolo ...
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Source: PubMed
Pharmacol Rep
Altered surface expression of P2Y11 receptor with narcolepsy-associated mutations.
Dommer MW, Dreisig K, Kornum BR
Narcolepsy with cataplexy is a neurological sleep disorder, which is believed to arise from the autoimmune destruction of hypocretin-producing neurons ...
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Source: PubMed
Sleep 2020 Jan 29
Narcolepsy Severity Scale: A reliable tool assessing symptom severity and consequences.
Dauvilliers Y, Barateau L, Lopez R, Rassu AL, Chenini S, Beziat S, Jaussent I
To define clinically relevant Narcolepsy Severity Scale (NSS) score ranges, confirm its main performances and sensitivity to medications, and determin ...
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Source: PubMed
