Biopsies are obtained from the different skin layers

A shave biopsy generally involves obtaining tissue specimens from the thin outer layer of skin, called the epidermis.

A punch biopsy generally involves obtaining tissue specimens from the epidermis. However, in some cases, a punch biopsy involves the dermis and subcutaneous tissue.

An Incisional biopsy generally involves obtaining tissue specimens from the deepest layer of skin, called the subcutaneous tissue.

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