Severe acute respiratory syndrome (SARS) is caused by a coronavirus, called SARS-associated coronavirus (SARS-CoV). The virus was first detected in 2003.
The last infected human case was reported in 2004. However, SARS is not claimed to have been eradicated, as it may still be present in its natural host reservoirs (animal populations) and can return into the human population in the future.
SARS usually spreads through close person-to-person contact. The hallmark symptoms of SARS include cough, breathing difficulty, high fever and other respiratory symptoms.
Currently available diagnostic tests have some limitations. Many of the tests are unable to accurately diagnose SARS early, when treatment is most needed.
Treatment of SARS includes patient isolation and supportive therapy with the use antipyretics, supplemental oxygen and ventilation support as needed. SARS is still a puzzle to scientists and poses challenges to the best of brains in search of viable treatment options. Several pieces of the puzzle are slowly falling into place, as the world awaits a treatment strategy to combat this condition.
The death rate from SARS is 9-12% of the total reported cases. The prognosis of SARS is poor in the elderly with the death rate being 50% in people aged above 65-years. Younger patients showed better recovery. In some patients, SARS results in severe long-term sequelae like pulmonary fibrosis, osteoporosis and femoral necrosis. This leads to complete loss of ability to work or take care of self due to which some of the patients suffer from major depressive disorder.
Thanks to modern medicine we are no longer forced to endure prolonged pain, disease, discomfort and wealth.
Latest Publications and Research on SARSCytotoxic macrocyclic diterpenoids from Jatropha multifida. - Published by PubMed
Specialization of CDK1 and Cyclin B paralog functions in a coenocystic mode of oogenic meiosis. - Published by PubMed
Design, synthesis and biological evaluation of a novel tubulin inhibitor 7a3 targeting the colchicine binding site. - Published by PubMed
Structure-Activity Relationships (SARs) of the Competence Stimulating Peptide (CSP) in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor Activation. - Published by PubMed
Combination attenuation offers strategy for live-attenuated coronavirus vaccines. - Published by PubMed