Last Updated on Jan 04, 2017

RTA Type 2

  • In proximal renal tubular acidosis (RTA), the first part of the tubule just after the glomerulus is affected. This part is involved in the reabsorption of bicarbonate. Loss of excess bicarbonate in the urine leads to acidosis.
  • This condition affects children suffering from a genetic disorder called Fanconi’s syndrome. It also occurs in other inherited diseases like cystinosis, hereditary fructose intolerance and Wilson's disease. It could also occur in patients suffering from rejection of transplanted kidney. Drugs such as ifosfamide, acetazolamide and outdated tetracycline could also cause the disease.
  • Children often show stunted growth. Complications include rickets or osteomalacia. Kidney stones are rare.
  • Treatment of proximal renal tubular acidosis involves dealing with the underlying cause. Alkalis like sodium bicarbonate and potassium citrate help to maintain normal acid – base balance. Vitamin D may be useful in maintaining the bone growth.


  1. Harrison’s Principles of Internal Medicine 17th edition
  2. Arvind Bagga and Aditi Sinha. Evaluation of Renal Tubular Acidosis. Indian J Pediatr 2007; 74 (7): 679-686

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