'Paa' - Not Progeria
Paa is a modern movie with a different concept! In this film, Amitabh Bachchan, in a rare role reversal, plays son to Abhishek Bachchan, his real-life son!
What is new one may ask-after all they are actors playing a part!
In Paa Amitabh dons the role of Auro, a teenager, with Progeria- a disease that has not yet stirred the interest of the visual media.
Abhishek Bachchan, meanwhile, has gone overboard emphasizing that the movie is not about Progeria but about Paa- son bonding! But why cant the movie be about Progeria and about drawing the attention of the masses to this ill- known disease? Whatever the intention of the film, the audience would definitely leave the theatres more enlightened (about a less- known illness) than they were, when they arrived to watch the film.
- Jason Ellison, a 15 year old victim of progeria
Latest Publications and Research on ProgeriaErythrocyte Senescence in a Model of Rat Displaying Hutchinson-Gilford Progeria Syndrome. - Published by PubMed
Genomic instability and DNA replication defects in progeroid syndromes. - Published by PubMed
Diminished canonical ί-catenin signaling during osteoblast differentiation contributes to osteopenia in progeria. - Published by PubMed
Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. - Published by PubMed