About - Peritoneal Cancer
The peritoneum is a membrane lining the inner surface of the abdomen. It also covers the outer surface of most organs in the abdominal cavity. It prevents friction between different organs and allows them to glide smoothly over one another. It is made up of 2 layers - the portion that lines the abdominal wall called parietal peritoneum and the portion that surrounds the organs called visceral peritoneum. The space between these 2 layers contains a small amount of fluid and is called the peritoneal cavity.
The primary cancers of peritoneum include peritoneal mesotheliomas, primary peritoneal carcinoma, and desmoplastic small round cell tumor. These cancers are rare but they often have a poor prognosis.
Peritoneal cancers cause vague symptoms like abdominal pain, distension and stomach upset; hence they are often diagnosed late. They are treated with surgery, chemotherapy and sometimes in addition radiation. A newer treatment approach includes removing the obvious cancer by a surgical procedure called Cytoreduction and then treating the patient with chemotherapy drugs instilled into the abdomen at a raised temperature through a procedure called Hyperthermic Intraperitoneal Chemotherapy.
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Latest Publications and Research on Peritoneal CancerRoles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens. - Published by PubMed
Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia. - Published by PubMed
Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence. - Published by PubMed
A systematic analysis highlighting deficiencies in reported outcomes for patients with stage IV colorectal cancer undergoing palliative resection of the primary tumour. - Published by PubMed
Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages. - Published by PubMed