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Parkinson's Disease

Parkinson's Disease

Author -  Vani Pradeep, MBA | Medically Reviewed by Dr. Nithin Jayan, MBBS, DNB on Mar 11, 2023
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What is Parkinsonís Disease?

Parkinson's Disease (PD, is also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome/HRS, or paralysis agitans) is a brain disorder and a progressive disease that leads to persistent movement disorder and worsens over time. It is caused by the loss of dopamine brain cells (neurons). The patient usually experiences uncontrollable shaking and tremors, slow movement, problems in standing up, difficulty in balancing and stiffness in the limbs. It mostly affects the middle-aged and elderly. Idiopathic Parkinsonís disease is the most common type and causes tremors, rigidity and slowness of movement. Although there is no permanent cure, medication and surgery are both available to manage its symptoms. Dr Richard Wade-Martins, University of Oxford is conducting a research on ĎTRAPing Parkinsonís Ė why do some cells die?í and he aims to find out why some cells die while others live.


What is New in Parkinson's Disease?

1. Effects of Binge Eating in Parkinson's Patients

Binge eating in Parkinson's patients was associated with cognitive abnormalities such as a working memory deficit, reveals a new study. Binge eating alters the mechanisms in Parkinson's patients and it is essential to understand them.

2. Do People With Parkinson's Disease Experience Symptoms of Demoralization?

People who have Parkinson's disease may show signs of depression, but that could actually be another condition disguised as depression, finds a new study. This psychological condition is called demoralization.

Causes of Parkinsonís Disease

Parkinsonís (PD) is a slowly progressive disease caused by the loss of dopamine brain cells (neurons). Dopamine, are brain cells produced in the substantia nigra of the brain. It is a neurotransmitter and a chemical messenger. Messages are transmitted between the substantia nigra and other parts of the body by dopamine. Dopamine brain cell death causes lesser dopamine. This causes impairment of movement in body parts.


Early Symptoms and Signs of Parkinsonís Disease

The symptoms of Parkinsonís disease begins when about 50 to 80 percent of dopamine neurons have died and it is hard for doctors to detect PD at its early stages. However, about 70 percent of people with the disease experience slight tremors in the hand and the foot over one side of the body. The symptoms are branched out to ĎPrimary Motor Symptomsí and ĎSecondary Motor Symptomsí.

Symptoms of ParkinsonÔŅĹs Disease

The Primary Motor Symptoms are as described here:

  • ďResting tremorĒ is usually experienced and happens when a personís muscles are completely relaxed. Typically, tremors on one finger are prominent.
  • ďSlow movementĒ also known as bradykinesia or movement disorder is another symptom that results in abnormal stiffness and decreases facial expression. A personís repetitive movements and routine functions are also often affected. This condition of slow movement may often lead to reduced speech.
  • ďRigidityĒ is yet another condition resulting in stiffness and the muscles do not relax like in a normal person. The person experiences rigidity in the neck, shoulder and legs.
  • ďPostural instabilityĒ is the most important sign of a PD patient. The person with this condition loses some reflexes essential for maintaining an upright posture. Patients with balance problem may have difficulty when turning around or pivoting or during quick movements.

Here is a list of Secondary Motor Symptoms:

  • Freezing causes fear to put the foot forward. The person feels that their feet are stuck to the ground. However it is a temporary feeling.
  • Micrographia is the result of a Parkinsonís patient whose handwriting shrinks. Mask-like Expression happens due to decreased and unconscious facial movements. A PD patient exhibits flexed posture resulting from rigidity and bradykinesia.
  • Unwanted accelerations occur in PD patients and cause trouble in speech and movement. People who experience festination face greater risks to falls.

Stages of Parkinsonís Disease

Stage I: This is the mildest stage of PD which least interferes with routine tasks. Tremors and other symptoms are restricted to one side of the body.

Stage II: It is a moderate stage in PD where stiffness, tremors and trembling can be noted and facial expressions may change. The symptoms are sensed on both sides of the body.

Stage III: This is the mid-stage in PD, which symbolizes a major change point in PD progression. In addition to loss of balance and decreased flexes, the symptoms mentioned in stage II also occur. Occupational therapy combined with medication may help in decreasing the symptoms.

Stage IV: In this progressive stage, it becomes difficult for the patient to move without a walker or other assistive device. However, the person can stand without assistance.

Stage V: This is the most advanced and debilitating stage of PD. Stiffness in legs may cause freezing when standing. Patients are frequently unable to stand without falling. They may experience hallucinations and occasional delusions.

Diagnosis of Parkinsonís Disease

In order to diagnose Parkinsonís disease, the physician takes a neurological history and executes an examination. Clinical information provided by the PD person and findings from neurological examination plays a key role in the diagnosis, as there are no standard diagnostic tests available. The observations carried out include:

  • The doctor examines the PD patientís expression
  • The patientís arms are observed for any tremors that may occur at rest or when extended
  • Stiffness in limbs or neck are observed
  • It is checked if the patient can rise from a chair easily
  • The patientís pattern of walking is observed; the patient may be walking in short steps.
  • It is examined if the patientís arms swing symmetrically
  • Also, the patientís quickness in regaining balance is checked
Regaining Balance in PD Patients

Prognosis of Parkinsonís Disease

Over the years, it has been concluded that most PD patients respond to medications. However, the duration of drug efficiency varies from one person to another. Movement disorder and also non-motor symptoms vary from person to person. These affect PD patients at all stages of the disease. For some PD patients, fatigue or depression may be more complicated to deal with than movement disorders.

Treatment for Parkinsonís Disease

In order to manage the symptoms of PD, it is common for PD patients to take an assortment of medications at different times and in different doses. A proper medication schedule provides great benefits to the patient. Certain classes of medication are available to treat PD. However, the exact condition of the patient and symptoms are diagnosed before prescribing the right combinations of medication and treatments.

Some of the Medications are mentioned below:

  • Carbidopa/ Levodopa Therapy
PD Treatment: Levodopa Therapy
  • Dopamine Agonists
  • Anticholinergics
  • MAO-B Inhibitors
  • COMT Inhibitors


  • Amantadine
  • Rivastigmine tartrate
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  1. The Michael J. Fox Foundation for Parkinson's Research - (https://www.michaeljfox.org/)
  2. Understanding Parkinson's - What Is Parkinson's? - (https://parkinson.org/understanding-parkinsons/what-is-parkinsons)
  3. Types of Parkinsonism - (https://www.parkinsons.org.uk/information-and-support/types-parkinsonism)

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It was after my Parkinson disease second P.T called my doctor about the weakness in my legs and arms, by this time I have developed a gait in my walk and I fell more frequently. Only then did my doctor send me to a specialist and it was found that I had Parkinson's and that I have had it for a while. I think because I was a woman that my signs and symptoms weren't taken seriously and therefore left untreated for so long,I was taking pramipexole dihydrochloride three times daily, I Was on carbidopa levodopa but only lasted 90 minutes then wore off. I found that none of the current medications worked effectively for me.I got tired of using those medications so I decided to apply the natural herbs formula that was prescribed to me by my second P.T, I purchase the herbal formula from WWW MADIBAHERBALCENTER COM   WhatsApp 16183561110 , There has been a huge progression ever since I start the treatment plan which will last for months usage. all the symptoms and signs begin to disappear and am fully back to my shop like nothing happen to me.


My husband who had been diagnosed with Parkinson’s disease for 2 years at the age of 75 had all his symptoms reversed with Ayurveda medicine from naturalherbscentre. com after undergoing their Parkinson’s natural protocol. God Bless all Parkinson’s Caregivers. Stay Strong, take small moments throughout the day to thank yourself, to love your self, and pray to whatever faith, star, spiritual force you believe in and ask for strength. I can personally vouch for these remedy but you would probably need to decide what works best for you.


I was diagnosed 2 years ago at age 63. Symptoms were tremor in right leg, loss of handwriting ability,My normally beautiful cursive writing was now small cramped printing and soft voice. I also had difficulty rising from a seated position and have balance issues. I started out taking only Azilect, then Mirapex, and then Sinemet. Several months ago I started falling frequently, hence the reason for Sinemet. During the summer of 2021, I was introduced to Health Herbs Clinic and their effective Parkinson’s herbal protocol. This protocol relieved symptoms significantly, even better than the medications I was given. Visit www . healthherbsclinic . com , After First month on treatment, my tremors mysterious stopped, had improvement walking. After I completed the treatment, all symptoms were gone. I live a more productive life. I was fortunate to have the loving support of my husband and family. I make it a point to appreciate every day!


I was around 58 when my thumb started giving me problems. As time passed i had other symptoms; hand tremors, restless sleep, muscle weakness, cognitive decline, voice spasm, stiff achy right arm and ankle. At 60 i was diagnose of PARKINSONS DISEASE, i was on Carbidopa and Pramipexole for two years, they helped alot but not for long. As the disease progressed my symptoms worsened, with my neurologist guidance i started on natural alternative PARKINSONS DISEASE treatment from R.H.F. [Rich Herbs Foundation], the treatment worked very effectively, my severe symptoms simply vanished, i feel better now than I have ever felt and i can feel my strength again. Visit ww w. richherbsfoundation. c om. My neurologist was very open when looking at alternative medicines and procedures, this alternative parkinson disease treatment is a breakthrough.


i have not seen the decease known now as " Restless leg syndrome mentioned in the list. can you include this RLS and medication for this please. mohan-muscat

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