Is it better to take Pioglitazone in the morning or at night?

Pioglitazone can be taken at any time of day , whether in the morning or evening, with or without food. Try to take it at the same time every day.

What is the black box warning for Pioglitazone?

The FDA issued a blackbox warning that the use of pioglitazone for the treatment of type 2 diabetes may increase the risk of bladder cancer .

Does Pioglitazone reduce cholesterol?

Pioglitazone can help with diabetic dyslipidemia by increasing HDL cholesterol and decreasing triglycerides . Increased HDL levels may have a positive effect on reverse cholesterol transport.

Can Pioglitazone and metformin taken together?

In comparison to metformin alone, pioglitazone plus metformin significantly improved glycemic control and markers associated with increased insulin resistance and cardiovascular risk.

Does Pioglitazone affect liver?

Pioglitazone has been linked to rare cases of acute liver injury . The liver damage caused by pioglitazone is usually reversed by discontinuing the medication.

Methemoglobinemia - References

References:

Methemoglobinemia - (https://www.nlm.nih.gov/medlineplus/ency/article/000562.htm)
Methemoglobinemia: from diagnosis to treatment - (http://www.scielo.br/scielo.php?pid=s0034-70942008000600011&script=sci_arttext&tlng=en)
Methemoglobinemia and Medications A to Z - (http://www.dpic.org/article/professional/methemoglobinemia-and-medications-z)
Methemoglobinemia: diagnosis - (https://www.openanesthesia.org/methemoglobinemia_diagnosis/)
Exchange transfusion - (https://www.nlm.nih.gov/medlineplus/ency/article/002923.htm)
Hyperbaric oxygen therapy - (http://www.mayoclinic.org/tests-procedures/hyperbaric-oxygen-therapy/basics/definition/prc-20019167)
Methemoglobinemia - (http://emedicine.medscape.com/article/204178-overview)
What is G6PD Deficiency - (http://www.g6pd.org/g6pddeficiency.aspx)
Methemoglobinemia, beta-globin type - (http://ghr.nlm.nih.gov/condition/methemoglobinemia-beta-globin-type)