What is Melioidosis?
Infectious diseases are diseases that are caused by organisms. Many organisms are known to cause disease, including bacteria, viruses, fungi or parasites. Infectious diseases can spread from person to person and by several other means. To ascertain whether a disease is infectious or not, certain criteria called Kochs postulates have to be met. Signs and symptoms of infectious diseases vary depending on the type of organism and the general condition of the patient, but fever and malaise are salient features of almost all infectious diseases. Infectious diseases in children usually differ in that the organisms causing the diseases are different and the immune capacity of children may not be strong enough to handle diseases that adults can usually handle. Based on the organism causing the disease, infectious diseases can be classified as:
- Prion disease
The disease caused by this bacterium encompasses a wide range of manifestations in the body, which range from no symptoms or signs at all, to a fatal dissemination of the bacterium in the blood. Several factors modulate the type of disease one might get.
Causes and Risk Factors of MelioidosisMelioidosis is caused by a bacterium called Burkholderia pseudomallei, which is found in soil and water. It can be transmitted by contact with contaminated soil and water.
The causative organism of melioidosis is a bacterium called Burkholderia pseudomallei. It was first described in 1911 in Burma by Alfred Whitmore and C.S.Krishnaswami.
Transmission of the bacterium can happen by several means:
- Inhalation of contaminated material
- Contact with contaminated material like soil through a break in the skin
- Drinking contaminated water
There are certain risk factors for the development of severe disease. These include the presence of conditions like:
- Diabetes mellitus
- Renal impairment
- Immunocompromised condition
- High alcohol consumption
- Chronic Lung Disease
Symptoms and Signs of MelioidosisMelioidosis usually presents with fever, body pain, breathing difficulty, and may sometimes cause rapid deterioration in health and also death.
The signs and symptoms of melioidosis depend on the type of infection caused, but none are pathognomonic.
This is usually caused due to infection through a break in the skin (inoculation). It presents as:
- Skin ulcer
- Skin nodule
- Skin abscess
Worldwide, this type of melioidosis is the most common. Again, the severity of disease can vary from mild symptoms of bronchitis to severe lung infection. Symptoms include:
- Cough with or without sputum production
- Breathing difficulty
- High fever
Patients who are immunocompromised, or who are already sick and have other risk factors, are likely to develop bloodstream infection and septic shock. The symptoms and signs include:
- High fever
- Altered mental status
- Respiratory distress
- Drop in blood pressure
- Joint pain
- Abscesses may be found throughout the body
Disseminated infection presents with abscesses in various parts of the body, which may or may not be associated with sepsis. The organs commonly affected are:
- Joints and bones
- Lymph Nodes
Diagnosis of MelioidosisThe diagnosis of melioidosis is based on culture and immunological tests. Imaging tests may also be needed.
The diagnosis of melioidosis in regions where it is not prevalent is difficult because it can mimic various diseases and because it is difficult to isolate.
- The best test to prove infection is blood culture and culture from the abscesses
- Other blood tests including cell counts, inflammation markers such as ESR, CRP and other routine tests are also done
- Immunologic tests are available, including:
- Complement Fixation
- Chest x-rays are taken to look for lung infection
- CT scan of the abdomen, chest or the brain may be necessary depending on the type of infection and the organ affected
- In some cases, MRI scan of the affected region may be done
Treatment for MelioidosisThe treatment of melioidosis is based on the use of specific antibiotics in two phases.
Treatment of melioidosis is standardized according to guidelines and involves specific antibiotics, used in two phases of treatment. On occasions, specialists may use other antibiotics based on culture results and their clinical judgment.
The standard treatment for melioidosis includes
Intensive phase, in which regimens containing some of the following drugs may be used:
- Filgrastim (G-CSF) in case of septic shock
Eradication phase, which may include some of the following drugs:
Latest Publications and Research on MelioidosisBurkholderia pseudomallei Adaptation for Survival in Stressful Conditions. - Published by PubMed
Transcriptomic analysis of longitudinal Burkholderia pseudomallei infecting the cystic fibrosis lung. - Published by PubMed
Genitourinary melioidosis in a Bangladeshi farmer with IgA nephropathy complicated by steroid-induced diabetes mellitus. - Published by PubMed
Soil characteristics influencing the spatial distribution of melioidosis in Far North Queensland, Australia. - Published by PubMed
Upregulation of Immune Process-Associated Genes in RAW264.7 Macrophage Cells in Response to Burkholderia pseudomallei Infection. - Published by PubMed