Latest Publications and Research on Skin Biopsy

Biochim Biophys Acta Gen Subj  2020 Jan 30  

Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.

Panwar P, Hedtke T, Heinz A, Andrault PM, Hoehenwarter W, Granville DJ, Schmelzer CEH, Brömme D

Skin ageing is associated with structure-functional changes in the extracellular matrix, which is in part caused by proteolytic degradation. Since cys... Read More

Source: PubMed

Biol. Blood Marrow Transplant.  2020 Jan 29  

Nilotinib treatment of patients affected by chronic graft-versus-host disease reduces collagen production and skin fibrosis by down-modulating the TGF-ß and p-SMAD pathway.

Busilacchi Elena M, Andrea C, Giorgia M, Giovanni T, Jacopo O, Antonella P, Nadia V, Luca B, Anna C, Gaia G, Daniela M, Olivieri A

The present study was conducted to investigate cellular and molecular features of chronic graft-versus-host disease fibroblasts (GVHD-Fbs) and to asse... Read More

Source: PubMed

Inflamm. Res.  2020 Jan 31  

Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation.

Barbosa GM, Cunha JE, Russo TL, Cunha TM, Castro PATS, Oliveira FFB, Cunha FQ, Ramalho FS, Salvini TF

To compare the unilateral signs of knee osteoarthritis (KOA) 30 and 60 days after anterior cruciate ligament transection (ACLT). Pain, gait function, ... Read More

Source: PubMed

J Biomech Eng  2020 Feb 03  

An Automated Kinematic Measurement System for Sagittal Plane Murine Head Impacts.

McInnes KA, Abebe Z, Whyte T, Bashir A, Barron C, Wellington C, Cripton PA

Mild traumatic brain injuries (mTBI) are typically caused by non-penetrating head impacts that accelerate the skull and result in deformation of the b... Read More

Source: PubMed

Sci Rep    

Fibroblast mitochondria in idiopathic Parkinson's disease display morphological changes and enhanced resistance to depolarization.

Antony PMA, Kondratyeva O, Mommaerts K, Ostaszewski M, Sokolowska K, Baumuratov AS, Longhino L, Poulain JF, Grossmann D, Balling R, Krüger R, Diederich NJ

Mitochondrial dysfunction is a hallmark in idiopathic Parkinson's disease (IPD). Here, we established screenable phenotypes of mitochondrial morpholog... Read More

Source: PubMed

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