Biochim Biophys Acta Gen Subj 2020 Jan 30
Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation.
Panwar P, Hedtke T, Heinz A, Andrault PM, Hoehenwarter W, Granville DJ, Schmelzer CEH, Brömme D
Skin ageing is associated with structure-functional changes in the extracellular matrix, which is in part caused by proteolytic degradation. Since cys ...
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Source: PubMed
Biol. Blood Marrow Transplant. 2020 Jan 29
Nilotinib treatment of patients affected by chronic graft-versus-host disease reduces collagen production and skin fibrosis by down-modulating the TGF-ß and p-SMAD pathway.
Busilacchi Elena M, Andrea C, Giorgia M, Giovanni T, Jacopo O, Antonella P, Nadia V, Luca B, Anna C, Gaia G, Daniela M, Olivieri A
The present study was conducted to investigate cellular and molecular features of chronic graft-versus-host disease fibroblasts (GVHD-Fbs) and to asse ...
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Source: PubMed
Inflamm. Res. 2020 Jan 31
Thirty days after anterior cruciate ligament transection is sufficient to induce signs of knee osteoarthritis in rats: pain, functional impairment, and synovial inflammation.
Barbosa GM, Cunha JE, Russo TL, Cunha TM, Castro PATS, Oliveira FFB, Cunha FQ, Ramalho FS, Salvini TF
To compare the unilateral signs of knee osteoarthritis (KOA) 30 and 60 days after anterior cruciate ligament transection (ACLT). Pain, gait function, ...
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Source: PubMed
J Biomech Eng 2020 Feb 03
An Automated Kinematic Measurement System for Sagittal Plane Murine Head Impacts.
McInnes KA, Abebe Z, Whyte T, Bashir A, Barron C, Wellington C, Cripton PA
Mild traumatic brain injuries (mTBI) are typically caused by non-penetrating head impacts that accelerate the skull and result in deformation of the b ...
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Source: PubMed
Sci Rep
Fibroblast mitochondria in idiopathic Parkinson's disease display morphological changes and enhanced resistance to depolarization.
Antony PMA, Kondratyeva O, Mommaerts K, Ostaszewski M, Sokolowska K, Baumuratov AS, Longhino L, Poulain JF, Grossmann D, Balling R, Krüger R, Diederich NJ
Mitochondrial dysfunction is a hallmark in idiopathic Parkinson's disease (IPD). Here, we established screenable phenotypes of mitochondrial morpholog ...
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Source: PubMed
