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Parkinsonís Disease - Causes, Symptoms, Diagnosis, Treatment

Written by Vani Pradeep, MBA | Medically Reviewed by Dr. Nithin Jayan, MBBS, DNB on Apr 06, 2018
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Latest Publications and Research on Parkinsons Disease

J Parkinsons Dis  2020 Jan 28  

An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts.

Padmanabhan S, Lanz TA, Gorman D, Wolfe M, Joyce A, Cabrera C, Lawrence-Henderson R, Levers N, Joshi N, Ma T, Liong C, Narayan S, Alcalay RN, Hutten SJ, Baptista MAS, Merchant K

The phosphorylated form of LRRK2, pS935 LRRK2, has been proposed as a target modulation biomarker for LRRK2 inhibitors. The primary aim of the study w... Read More

Source: PubMed

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Nat Commun    

Human and mouse essentiality screens as a resource for disease gene discovery.

Cacheiro P, MuŮoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V, Lelliott CJ, Wardle-Jones H, Wells S, Teboul L, Cater H, Stewart M, Hough T, Wurst W, Sedlacek R, Adams DJ, Seavitt JR, Tocchini-Valentini G, Mammano F, Braun RE, McKerlie C, Herault Y, de Angelis MH, Mallon AM, Lloyd KCK, Brown SDM, Parkinson H, Meehan TF, Smedley D

The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific know... Read More

Source: PubMed

J. Biol. Chem.  2020 Jan 31  

Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.

Kumari R, Kumar R, Kumar S, Singh AK, Hanpude P, Jangir D, Maiti TK

Parkinson's disease (PD) is a multifactorial malady and the second most common neurodegenerative disorder, characterized by loss of dopaminergic neuro... Read More

Source: PubMed

J Integr Med  2020 Jan 16  

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review.

Shinjyo N, Parkinson J, Bell J, Katsuno T, Bligh A

A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of ... Read More

Source: PubMed

BMC Neurol    

Protocol of a randomized open label multicentre trial comparing continuous intrajejunal levodopa infusion with deep brain stimulation in Parkinson's disease - the INfusion VErsus STimulation (INVEST) study.

van Poppelen D, Sisodia V, de Haan RJ, Dijkgraaf MGW, Schuurman PR, Geurtsen GJ, Berk AEM, de Bie RMA, Dijk JM

Both Deep Brain Stimulation (DBS) and Continuous intrajejunal Levodopa Infusion (CLI) are effective therapies for the treatment of Parkinson's disease... Read More

Source: PubMed

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Comments

everlyray09

I was around 58 when my thumb started giving me problems. As time passed i had other symptoms; hand tremors, restless sleep, muscle weakness, cognitive decline, voice spasm, stiff achy right arm and ankle. At 60 i was diagnose of PARKINSONS DISEASE, i was on Carbidopa and Pramipexole for two years, they helped alot but not for long. As the disease progressed my symptoms worsened, with my neurologist guidance i started on natural alternative PARKINSONS DISEASE treatment from R.H.F. [Rich Herbs Foundation], the treatment worked very effectively, my severe symptoms simply vanished, i feel better now than I have ever felt and i can feel my strength again. Visit ww w. richherbsfoundation. c om. My neurologist was very open when looking at alternative medicines and procedures, this alternative parkinson disease treatment is a breakthrough.

mohann

i have not seen the decease known now as " Restless leg syndrome mentioned in the list. can you include this RLS and medication for this please. mohan-muscat

gsadha

Zandopa is the best available cure for Parkinson's Disease. It is a herbal product and hence there is no damage in the long run.

meeta shah

I am sujok therapidt and giving treatmeny to parkinsion's patient.he is 72 years old.he becomes vibront in movement and feeling uncomfortable.During my treatment ,he felt relax for 10 hrs. that day.I am usuing needle accupuncture system of byol meridians and chakras and triorigine in sujok therapy.

alex63

I am Acupuncture therapist myself ans have PD for 3 years. So farI have not been able to control my Tremor [ mainly on Left side of the body]. Would you be so kind and share you approach with Su Jok (I do practice it as well). Thanks a lot! Alex

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