Global variation in anastomosis and end colostomy formation following left-sided colorectal resection.
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and... Read More
J Clin Neurosci 2019 Dec 28
The matter of significance - Has the p.(Glu121Lys) variant of TOR1A gene a pathogenic role in dystonia or Parkinson disease?
Milanowski L, Hoffman-Zacharska D, Geremek M, Friedman A, Figura M, Koziorowski D
Next Generation Sequencing (NGS), has now become a very powerful tool for decoding variants of genes involved in pathogenesis of number of human disor... Read More
Int J Mol Sci
High Fat Diet Suppresses Peroxisome Proliferator-Activated Receptors and Reduces Dopaminergic Neurons in the Substantia Nigra.
Kao YC, Wei WY, Tsai KJ, Wang LC
Although several epidemiologic and animal studies have revealed correlations between obesity and neurodegenerative disorders, such as Parkinson diseas... Read More
Brain Res. 2019 Dec 28
DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN.
Niki T, Endo J, Takahashi-Niki K, Yasuda T, Okamoto A, Saito Y, Ariga H, Iguchi-Ariga SMM
DJ-1 was identified as an oncogene and also as a causative gene for a familial form of Parkinson disease (PD). DJ-1 plays various roles in anti-oxidat... Read More
Aging (Albany NY)
Ŗ-arrestin2 alleviates L-dopa-induced dyskinesia via lower D1R activity in Parkinson's rats.
Zhang XR, Zhang ZR, Chen SY, Wang WW, Wang XS, He JC, Xie CL
The cause of the L-dopa-induced dyskinesia (LID) has been ascribed to G-protein coupled receptor (GPCR) supersensitivity and uncontrolled downstream s... Read More