Microscopic Polyangiitis (MPA) - Cause - Symptoms - Signs - Diagnosis - Treatment

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Latest Publications and Research on Microscopic Polyangiitis

Rheumatology (Oxford)  2013 Apr 12  

Fatigue-related brain white matter changes in granulomatosis with polyangiitis.

Basu N, Murray AD, Jones GT, Reid DM, Macfarlane GJ, Waiter GD

School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK.

Objective. To determine the association between brain white matter (WM) damage and persistent fatigue among patients with granulomatosis with polyangi... Read More

Source: PubMed

Am. J. Kidney Dis.  2013 Apr 9  

Computed Tomography Angiography in the Diagnosis of ANCA-Associated Small- and Medium-Vessel Vasculitis.

Dhaun N, Patel D, Kluth DC

Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom; Department of Renal Medicine, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. Electronic address: bean.dhaun@ed.ac.uk.

Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically occurs without detectable antineutrophil cytoplasmic antibody. It leads... Read More

Source: PubMed

Mod Rheumatol  2013 Apr 12  

Validation of the 2010 histopathological classification of ANCA-associated glomerulonephritis in a Japanese single-center cohort.

Togashi M, Komatsuda A, Nara M, Omokawa A, Okuyama S, Sawada K, Wakui H

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita City, Akita, 010-8543, Japan.

OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephriti... Read More

Source: PubMed

Medicina (B Aires)    

[Anti-neutrophil cytoplasmic antibody-associated vasculitis. Clinical aspects and treatment].

Paolini MV, Ruffino JP, Fernández Romero DS

Unidad de Inmunología e Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires. E-mail: virpaolini@gmail.com.

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis, comprise a group of diseases characterized by inflammation of the wall of small ves... Read More

Source: PubMed

Ren Fail  2013 Apr 8  

Gabexate Mesylate as Treatment in the Course of ANCA-Negative Microscopic Polyangiitis.

Gigante A, Gasperini ML, Barbano B, Liberatori M, Sardo L, Jovanovic T, Giannakakis K, Cianci R, Amoroso A

Department of Nephrology, Sapienza University of Rome , Rome , Italy.

Patients with small vessel vasculitis present fluctuating antineutrophil cytoplasmic antibodies (ANCA) levels to the point that positive ANCA may be m... Read More

Source: PubMed

Case Rep Med    

Hearing loss and kidney dysfunction: finding a unifying diagnosis.

Iruku P, Karanth P, Tiu H, Kankam C, Shaheen K

Department of Medicine, Case Western Reserve University, St. Vincent Charity Medical Center, Cleveland, OH 44115, USA.

Microscopic polyangiitis (MPA) is a systemic vasculitis that affects small caliber vessels, with renal and lung compromise. Diagnosis can be challengi... Read More

Source: PubMed

Best Pract Res Clin Rheumatol    

Fertility and pregnancy in vasculitis.

Pagnoux C, Mahendira D, Laskin CA

Vasculitis Clinic, Division of Rheumatology, Mount Sinai Hospital, University Health Network, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada. Electronic address: cpagnoux@mtsinai.on.ca.

Despite the rarity of vasculitides, fertility and pregnancy outcome in the setting of vasculitis have become a major topic of interest within the past... Read More

Source: PubMed

Best Pract Res Clin Rheumatol    

ANCA-associated vasculitis and malignancy: Current evidence for cause and consequence relationships.

Mahr A, Heijl C, Le Guenno G, Faurschou M

Department of Internal Medicine, University Hospital Saint-Louis, Paris, France. Electronic address: alfred.mahr@sls.aphp.fr.

In this review, we summarise the current understanding of the potential link between cancer and anti-neutrophil cytoplasmic antibody-associated vascul... Read More

Source: PubMed


Plasma exchange and glucocorticoid dosing in the treatment of anti-neutrophil cytoplasm antibody associated vasculitis (PEXIVAS): protocol for a randomized controlled trial.

Walsh M, Merkel PA, Peh CA, Szpirt W, Guillevin L, Pusey CD, Dezoysa J, Ives N, Clark WF, Quillen K, Winters JL, Wheatley K, Jayne D

Departments of Medicine and Clinical Epidemiology & Biostatistics, Marian Wing, Division of Nephrology, McMaster University, St, Joseph's Hospital, 50 Charlton Ave East, Hamilton, ON L8S 4A6, Canada. lastwalsh1975@gmail.com.

Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-ne... Read More

Source: PubMed

Monaldi Arch Chest Dis    

Pulmonary fibrosis presenting as an early manifestation of microscopic polyangiitis.

Eleftheriou D, Katsenos S, Zorbas S, Griveas I, Psathakis K

Department of Pneumonology, Army General Hospital of Athens, Athens, Greece.

Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis that is included in the pulmonary-renal syndromes. Although glomerulonephritis re... Read More

Source: PubMed


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I would like to connect with others that have this disease. What treatments have you tried, what has helped, what type of specialist do you see, etc. I have had this disease for a very long time but it has only been recently that a biopsy of my kidney was done and this disease diagnosed. I currently see a nephrologist, am on cellcept...had 4 infusions of rituxan. What symptoms do you have? Rosemary85


My husband was diagnosed [after several hospitalizations with undiagnosed symptoms..high potassium, etc.] in May 2011. His kidneys have not responded to treatments. He is on dialysis. No doctors in our area are skilled in treatment. He developed infections requiring hospitalization when trying cytoxin. He is trying to be approved for rituxan. Did it help? He is fatigued, and he is in pain in his back and legs.

The rituxan I had in August is helping in reducing some of the inflammation....you can see improvement over the course of a year after the treatment. I take cellcept, did the 4 treatments [infusions] of rituxan and on prednisone. I live in N. Idaho...where are you from?

my husband has this disease, he has been on cytoxin, white blood cell count bottomed out twice. We are trying to get approved for rituxan, could you tell me about your experience with rituxan? Thank you sandy

A very informative article! Autoimmune diseases such as this significantly affects one's life. I hope that diseases such as this one will have a cure in the near future so that suffering will be alleviated.


I was diagnosed with MPA in 2007. I was given cyclosphomide, prednisone and other toxic medicine that threw the illness into remission. Eventually the toxic drugs were replaced with milder ones and in the Spring of 2010 I was gradually taken off the drugs. I take raprinil, not so much for blood pressure control, but more to protect my kidneys that took a hit back in 2007 before I was diagnosed. Prior to the attack I had survived two battles with breast cancer, but the pain of MPA made the cancer seem like a walk in the park. They say that I am still in remission, and for a while I forgot and worked in the garden breaking concrete, planting trees, moving furniture around and this after working full-time 5 days a week. Then recently, I noticed the rash on my ankles, inflamed sinuses, fatigue going up the stairs, dropping things, losing my balance. It happens when I get tired and then I remember, MPA is still in the background.

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